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17 Cards in this Set
- Front
- Back
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Percentage of adults with associated occult malignancy?
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25%
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Children with DM have increased risk of what?
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Small vessel vasculitis and calcinosis cutis but NO increased risk of malignancy
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Skin disease precedes onset of malignancy by how long?
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2-3 months
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Main drug leading to DM?
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hydroxyurea (can also be NSAIDS, TNF inhibitors, statins, omeprazole)
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Nail findings in DM?
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ragged cuticles, nailfold telangiectasias, calcinosis cutis, mechanics hands (palmar erythema and hyperpigmentation, thickening, fissures), bullous lesions (poor prognosis)
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Wong variant?
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DM with PRP-like lesions
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Which kind of esophageal involvement requires steroids?
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Proximal (striated muscle)
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What increases the risk of diffuse interstitial fibrosis in DM?
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Jo1 postiivity
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Most common cancers in DM?
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ovarian, colon, GU, nasopharyngeal carcinoma in Asians
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Affected gene in juvenile DM?
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TNF-alpha 308A allele increased thrombospondin 1 small vessel occlusion
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Clinical features of juvenile DM?
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periorbital edema, increased risk small vessel vasculitis, lipodystrophy (distinguishing feature of JDM, panniculitis, calcinosis cutis)
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What is Brunsting type of JDM?
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Slower, progressive, steroid responsive
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Banker type of JDM?
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Faster onset of severe weakness, steroid unresponsive
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Stain to use for mucin?
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Colloidal iron
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Best muscle to biopsy?
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Triceps
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P155/p140?
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Cancer-associated myositis in adult DM, severe cutaneous disease in kids or adults (P140 is for JDM with calcinosis)
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Most sensitive JDM marker?
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Annexin XI
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