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15 Cards in this Set
- Front
- Back
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1. Early-Onset Sepsis Syndrome?
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a. Neonatal sepsis occurring in the first 6 days of life.
b. The majority of infection (approx 85%) occurs in the first 24 hours of life, an additional 5% by approximately 48 hours, and the remainder throughout the next 4 days. c. The infection source usually is microorganism acquisition from the mother’s GU tract. |
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2. Group B strep (GBS) colonization?
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a. Infection w/GBS limited to mucous membrane sites in a healthy adult.
b. The GI tract is the most common colonization reservoir. |
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3. Late-Onset Sepsis syndrome?
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a. Neonatal sepsis usually occurring after 7 days but before 90 days.
b. The infection source often is the caregiver’s environment |
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4. Intrapartum abx prophylaxis?
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a. IV PCN or ampicillin given during labour to prevent newborn GBS disease.
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5. How is overwhelming shock manifested in newborns?
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a. Pallor and poor capillary refil.
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6. Neonatal lab findings for sepsis (can be nonspecific)?
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a. Hypoglycemia
b. Metabolic acidosis c. Jaundice |
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7. Evidence of infection on CBC?
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7. Evidence of infection on CBC?
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8. What test is crucial for pts w/suspected sepsis?
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a. Blood culture.
b. Some argue, that the low meningitis incidence, esp in early-onset disease, does not warrant routine CSF testing; rather, the test should be reserved for documented (positive cultures) or presumed (pts so sick that a full abx course is to be given regardless of culture results) sepsis. |
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9. When are urine cultures included?
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a. For late-onset disease evaluation.
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10. Specific organisms that commonly cause early-onset sepsis?
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1. GBS
2. E. coli 3. Haemophilus influenzae 4. Listeria monocytogenes |
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11. Common organisms that cause late-onset disease?
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1. Coagulase-negative staph
2. S. aureus 3. E. coli 4. Klebsiella 5. Pseudomonas 6. Enterobacter 7. Candida 8. Serratia 9. Acinetobacter 10. Anaerobes |
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12. Most common cause of neonatal sepsis (birth to 3 months)!?!?!
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a. Group-B strep.
b. Approximately 80% of cases occur as early-onset disease (septicemia, pneumonia, meningitis) resulting from vertical transmission during L&D. |
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13. Initial clinical findings in more than 80% of neonates w/early-onset disease?
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a. Respiratory signs: apnea, grunting respirations, tachypnea, or cyanosis) regardless of the site of involvement
b. Hypotension is the initial findings in 25% of cases. |
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14. Sx of Neonatal GBS meningitis?
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a. Rarely have seizures as a presenting sign, yet 50% develop seizures w/24 hours of infection.
b. Note: median age of diagnosis of early-onset GBS is 13 hours, earlier than that for other bacterial infections described above. |
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15. Clinical hx and findings suggestive of early-onset GBS disease (rather than of a noninfectious aetiology for pulmonary findings)?
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a. Prolonged rupture of membranes
b. Apnea c. Hypotension in first 24 hours of life d. 1-minute Apgar <5 e. Rapid progression to pulmonary disease. |
