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26 Cards in this Set

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first generation cephalosporin PO
1) Cephalexin (Keflex)
2) Cephadroxil (Duricef)
3) Cepharadine (Velosef, Anspor)
1st generation CS, IV
1) Cefazolin (Ancef, Kefzol)
2nd generation CS, PO
1) Cefaclor (Ceclor)
2) Cefuroxime (Ceftin)
3) Cefprozil (Cefzil)
4) Loracarbef (Lorabid)
2nd generation CS, IV
1) Cefoxitin (Mefoxin)
2) Cefuroxime (Zinacef)
3) Cefotetan (Cefotan)
3rd generation CS, PO
1) Cefixime (Suprax)
2) Cefpodoxime (Vantin)
3) Cefibuten (Cedax)
3rd generation CS, IV
1) Cefotaxime (Claforan)
2) Cefoperazone (Cefobid)
3) Ceftizoxime (Cefizox)
4) Ceftriaxone (Rocephin)
5) Ceftazidime (Fortaz)
4th generation CS
1) Cefepime (Maxipime)
3rd generation CS, CNS
adequate to tx susceptible gm neg. meningitis
1,2,3 generation CS
good for gm. neg.
(Ecoli, P.mirabilis, Klebsiella)
1st gene. CS use
1) not DOC for anything
2) surgical prophylaxis
3rd gene. CS
Cefotaxime, Cefixime, Ceftriaxone are DOC for?
1) typhoid fever
2) gonorrhea
adverse effects of CS
1) hypersensitivity
2) thrombophlebitis
3) pseudomembranous colitis
4) superinfections
5) disulfiram-like reaction with alcohol
6) synergy with nephrotoxic drugs
DOC for gonorrhea
1) Ceftriaxone
2) Cefixime
DOc for enterobacteriaceae
(E-coli, Klebsiella, Proteus, Providencia stuartii, Serratia)
3rd gene.
DOC for H. flu meningitis
1) Ceftriaxone
2) Cefotaxime
DOC for typhoid fever
Ceftriaxone
prophylaxis for clean sx
Cefazolin
prophylaxis for dirty sx (colorectal sx, appendectomy, hysterectomy)
Cefoxitin or Cefotetan
other beta lactams
1) Imipenem (Primaxin)
- Meropenem (Meprem)
2) Aztreonam (Azactam)
Imipenem and Meropenem = DOC for
1) enterobacter
2) citrobacter freundi
3) acinetobactor
4) C. fetus
Adverse effects of Imipenem
1) hypersensitivity
2) superinfections
3) seizures
Aztreonam (Azactam)
a monobactam (single-ring beta-lactam from bacteria)
Aztreonam only covers
aerobic gram neg. bacteria
(Enterobacteriaceae, gonococci, H.flu)
Aztreonam is reserved for
very serious gram neg. infections resistant to less expensive drugs
Aztreonam is effective for
1) pneumonia
2) septicemia
3) PID infe.
4) intra-abd. infe.
5) CUTI
SE of Aztreonam
1) similar to other beta-lactams
2) presumed safe to use in PCN allergy
3) gram pos. superinfections