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14 Cards in this Set
- Front
- Back
1st generation spectrum
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Staph aureus (- MRS)
corynebacterium |
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1st generation ceph
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cehalothin, cefazolin, cephalexin, cefadroxil
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2nd generation ceph
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cefoxtin, cefotetan, cefaclor
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2nd generation spect
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e. coli, klebsiella, enterobacter, proteus, bacteroides fragilis
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3rd generation ceph
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pseudomonas all gram neg enteric micorobes
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4th generation ceph
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cefepime
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4th generation ceph spetrum
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pseudomonas esbl producing klebsiella and e. coli
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mech of action of ceph
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inhibit cell wall formation by binding transpeptidase
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pharmacokinetics of ceph
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well absorbed orally in simple stomach not ruminants, and in highly perfused tissue, excreted by kidney P.C.T
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cephalothin and cephapirin
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metabolized to desacetyl derivative in liver
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probenecid
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inhibits the active secretion of those drugs secreted via pct prolonging the effect
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side-effects of ceph
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nephrotoxicity hypersensitivity gi disturbance hypoprothrombinemia
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mechanism of resistance ceph
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production of beta-lactamase which destructs the structure
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cefpodoxime proxetil
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has a really long half life so it is given less frequently
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