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20 Cards in this Set
- Front
- Back
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tumor suppressors (Rb and p53) normally inhibit which phase progression?
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G1 >> S
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(cell type)
neurons, skeletal and cardiac muscle, RBCs |
Permanent
remain in G0 regenerate from stem cells |
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(cell type)
hepatocytes, lymphocytes |
Stable/quiescent
Enter G1 from G0 when stimulated |
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(cell type)
bone marrow, gut epithelium, skin, hair follicles |
Labile
Never go to G0 divide rapidly with a short G1 (continuous) |
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site of synthesis of secretory (exported) proteins and of N-linked oligosaccharide addition to many proteins
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RER
goblet cells of GI and Ab-secreting plasma cells |
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site of steroid synthesis and detoxification of drugs and poisons
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SER
liver hepatocytes and in adrenal cortex |
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HYPERphosphorylation of Rb leads to...
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retinoblastoma
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HYPOphosphorylation of Rb leads to...
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suppression of expression. (no movement to S phase)
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coarse facial features, clouded corneas, restricted joint movement and high plasma levels of lysosomal enzymes
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failure of addition of mannose-6-phosphate to lysosome proteins (enzymes are secreted outside the cell instead of being targeted to the lysosome); fatal in childhood
I-cell disease (inclusion cell disease) |
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distribution center of proteins and lipids from ER to the plasma membrane, lysosomes, and secretory vesicles
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Golgi apparatus
COPI -- retrograde COPII -- anterograde Clathrin -- trans/receptor-mediated endocytosis |
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recurrent pyogenic infections, partial albinism, peripheral neuropathy
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microtubule polymerization defect >>> decreased phagocytosis
Chediak-Higashi syndrome |
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ATPase that links peripheral 9 doublets and causes bending of cilium by differential sliding of doublets
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Axonemal dyenin
defect = Kartagener's syndrome |
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(type of collagen)
bone, skin, tendon, dentin, fascia, cornea, late wound repair |
Type I (90%)
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(type of collagen)
cartilage (incl hyaline), vitreous body, nucleus pulposus |
Type II
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(type of collagen)
skin, blood vessels, uterus, fetal tissue, granulation tissue |
Type III (Reticulin)
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(type of collagen)
basement membrane or basal lamina |
Type IV
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inhibited hydroxylation of proline and lysine residues in ER
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Scurvy
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defective glycosylation of pro alpha-chain of collagen
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Osteogenesis imperfecta
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defective peptide cleavage at terminal regions of procollagen >> no tropocollagen and/or crosslinked fibrils
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Ehlers-Danlos
Type III collagen |
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multiple fractures with minimal trauma, blue sclerae, hearing loss, dental imperfections
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brittle bone disease
AD with abnormal Type I collagen Type II is fatal in utero/neonatal period |
