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16 Cards in this Set

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Early Hypoxic Rxn
Dec Ox-Phos & ATP Synth
Fail Na/K/ATPase
Inc intracell Na
Dec intracell K
Swell Mito/ER & DisAgg Ribos
Stim Phosphfructokinase Act
Late Hypoxic Rxn
Still Reversible
Myelin Figures
Cell Blebs
Cell Death
(Point of No Return)
Damage Cell Mem
Massive Ca2+ influx
Calcify Mito
Intracell Enz released
Hypoxic Injury become Irrev
3-5 min: Neurons
(Purkinje of Hippo most sus)
1-2 hrs: Myocardial/Hepatocyt
Mult Hrs: Skel Muscle
Generate O2 Free Radicals
O2 Toxicity (alveolar damage)
Radiation/UV
Barbituate Tox
(Induce CYP450/hyprtrphy SER)
Reperfusion
Coagulative Necrosis
Sudden cutoff of bld supply
PRESERVE TISSUE ARCHITEC
organs w/limited collateral
Nuclear chngs (pyknosis, etc)
Liquefactive Necrosis
Ischemic Injury to CNS
Or Suppurative Infec
Caseous Necrosis
Granulomatous Inflam
(chez-like)
ex:TB
Gangrenous Necrosis
Lower extremity/Bowel
Wet: with liquefactive
Dry: with coagulative
Fibrinoid Necrosis
Deposit fibrin like mat in A. wall
Imm-Med Vasc Damage
Apoptosis
Bleb, Bud, Phagocytose
Extrinsic Path: FAS/FAS-L
(caspase8/9 init=proteases)
Intrinsic: (mitochondrial)
(loss stim by GF, bax/bak act caspase9)
Cytotoxic T cell Act Apop
Granzyme B and Perforins
See "laddering" DNA
Reg of Apop
bcl-2= Inhib
bax= facil
p53= facil
(dec bcl-2 and inc bax)
Hemochromatosis
Mut Hfe gene on Chromo 6
Triad: Micronodular Cirrhosis
DM, Skin pigmnt (bronze DM)
Inc Srm Iron/Dec TIBC
Lipofuscin
yellowish "wear and tear"
Brown Atrophy
Dystrophic Calcification
Calcify prev injured tissue
NOT bc Hypercalcemia
(Ca2+ conc is norm)