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15 Cards in this Set
- Front
- Back
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CAM
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Cell Adhesion Molecules
Main Clinical Pathologies involving CAMs: CANCER Metastasis Thrombosis Inflamation |
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Cadherins
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Calcium dependent CAMs which link homophilic adhesion to cell proliferation via catenins
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What causes Kallmann Syndrome and How does it present?
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Mutations/absent in the KAL1 gene cause the X-linked syndrom
Participates in migration of GnRH from olfactory to hypothalmus Incomplete sexual development Arm span can be huge |
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E-Cadherin
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Essential in junction formation & development of epithelial polarity
Expression is frequently DOWNREGULATED in CARCINOMAS |
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Melanoma
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Associated with a switch from E-Cadherin to N-Cadherin expression
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Prostate Cancer
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Associated with DOWNregulation of E-cadherin and UPregulation of N-cadherin
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Breast Cancer
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Lack of E-cadherin expression
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How do the cells move/migrate?
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Condensation mediated by caherins and intracellular catenins
Cadherin provides a moleculas stratum for cells to crawl over each other thereby extending the tissue |
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Catenin
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Genetic regulatory protein
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Naxos disease
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De;etion of the gamma catenin gene
Wooly hair Thickening of skin Hand/Feet Chest pain/rapid heart rate even cardiac death |
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Colorectal Cancer
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Mutation of the APC gene (polops) present in 80%
Also can involve hypermethylation of APC promotor region Loss of APC function earliest event can be detected at ACF |
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N-Cams
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Critical in brain development
Function by both homphilic and heterophilic adhesion |
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PSA-NCAM
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Increase spacing between cells in tissues
Abnormal expression in cancer increases tumor aggressiveness |
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Desmogleins
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Targets for autoimmune anibodies in pt. with PEMPHIGUS
And bacterial toxins in pt. with STAPHYLOCOCCUS |
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Leulcocyte Adhesion Deficiency
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Hematologic disorder of INTEGRIN function mutation of B2-INTEGRIN
Difficult to detect early |
