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16 Cards in this Set
- Front
- Back
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Main cell in acute inflammation
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Neutrophil
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Main cell in chronic inflammation
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Lymphocytes T and Band macrophages, plasma cells
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Three main components of acute inflammation
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Local hyperemia, vascular permeability, leukocyte emigration
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What cells constitutie chemical junk?
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Leukocyte activation-->AA-->prostaglandins and leukotrienes
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What are the eicosanoids?
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Leukotrienes and prostaglandins
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Which cells cause acute phase reactions
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IL-1, Il-6 and TNF
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Which cells are used in ESR?
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Fibrinogen and CRP
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What is NO
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Cytokines, TNF; vasodilation; hypotensive effects of septic shock
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Describe type 1 hypersensitivity early stage
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CD4 T cells, IL 4 and 5, IgE production by B and Mast cell grows, histamine is released
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Describe type 1 hypersensitivty late stage
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Phosphoselipase produces AA which produces prostaglandins and leukotrienes
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What are the three subtypes of Hypersensitiivty 2
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ADCC, Complement dependent, and antibody mediated
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Describe ADCC
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Neutrophil, eosinophil and macro or NK binds to Fc part of IgG and antigen binding region binds to antigenic component
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Describe complement dependent reaction
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transfusions, erythroblastosis fetalis, autoimmune anemia
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Describe antibody mediated cellular dysfunction
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Grave's disease and myasthenia gravis
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Type 3 hypersensitivity reactions
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Immune complex's attach to vasulcar endothelium and cause activation of complement; PMNs; cause glomerulonephritis
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Type 4 hypersensitivity
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delayed type hypersensitivity which is Cd4 and direct cell which is CD8
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