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28 Cards in this Set
- Front
- Back
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MOA penicillin
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1) bind PBPs 2) block transpeptidase crosslinking cell wall 3) activate autolytic enzymes
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penicillin mostly used for
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g(+), syphillis
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name 3 penicilinase resistant penicillins
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methicillin, nafcillin, dicloxacillin
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use of penicillinase resistant penicillins
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S. aureus
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coverage of aminopenicillins
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g(+), HELPS: H flu, E coli, Listeria, Proteus, Salmonella
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name 2 aminopenicillins
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amoxicillin, ampicillin
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name 3 antipseudomonals
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ticarcillin, carbenicillin, piperacillin
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name 3 beta lactamase inhibitors
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CAST: clavulinic acid, sulbactam, tazobactam
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1st gen cephalosporin coverage
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PEcK: proteus, E coli, Klebsiella, g(+) cocci
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2nd gen cephalosporin coverage
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HEN PEcKs: H flu, Enterbacter, Neisseria, Proteus, E coli, Klebsiella, g(+) cocci
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3rd gen cephalosporin coverage
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serious g(-) infections
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4th gen cephalosporin coverage
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pseudomonas, g(+) organisms
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which cephalosporin for pseudomonas?
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ceftazidime, cefepime
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which cephalosporin for gonorrhea
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ceftriaxone
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MOA cephalosporins
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beta lactam - inhibit cell wall synthesis
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MOA aztreonam
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monobactam R to beta lactamases - inhibit cell wall synthesis by binding to PBPs
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coverage of aztreonam
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g(-) rods only
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which drug synergistic to aminoglycosides
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aztreonam
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which cell wall synthesis inhibitor for penicillin allergies
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aztreonam
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what is always given w/ imipenem
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cilastatin
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MOA cilastatin
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inhibits renal dihydropeptidase I to decrease inactivation of imipenem
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coverage of imipenem
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g(+) cocci, g(-) rods, anaerobes
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MOA vancomycin
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inhibits cell wall mucopeptide formation by binding D-ala, D-ala
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coverage of vancomycin
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g(+) only, inc MRSA, C diff
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which drug increases aminoglycoside nephrotox?
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cephalosporins
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which drug has disulfiram-like reaction w/ ethanol?
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cephalosporins
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SE of Vancomycin?
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nephrotox, ototox, thrombophlebitis, red-man syndrome
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prevent red man syndrome by giving
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anti-histamine
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