Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
19 Cards in this Set
- Front
- Back
|
cell mediated immunity
|
cells attacking cells
provided by T-cell lymphocytes |
|
|
step 1
|
antigen presenting cell phagocytizes antigen/pathogen (macrophage or monocyte or dendritic cell)
|
|
|
step 2
|
enters lymphatic tissue (lymph node)
|
|
|
step 3
|
presents antigen/pathogen to a population of T-cells
|
|
|
step 4
|
specific T-cells recognizes antigen
|
|
|
step 5
|
"activates"--> enlarges and undergoes many mitotic divisions to form a clone
|
|
|
5) a. memory T-cells
|
turned off and stored for later use
|
|
|
5) b. helper T-Cells
|
(CD4) required for both sides of immunity
secrete cytokines (interleukins 2,4,5) |
|
|
5) c. Cytotoxic T-cells
|
CD8, killer T-cells
-effector cell; leaves lymphatic tissue on a search and destroy mission |
|
|
cytotoxic t-cells may estroy target cells/pathogens directly by secreting:
under c. |
granzymes
perforin granulyson lymphotoxin |
|
|
granzymes
|
protein-digesting enzymes; destroy target cells by releasing pathogens
|
|
|
perforin
|
protein channels; allow body fluid to enter the cell
cytolysis (cell rupture) |
|
|
granulyson
|
inserted into perforin channels to destroy pathogens
|
|
|
lymphotoxin
|
DNA fragmenting enzyme
|
|
|
cytotoxic T-cells destroy target cells/pathogens in INDIRECTLY by secreting
|
gamma interferon
macrophage migration inhibition factor |
|
|
gamma interferon
|
chemotactic agent for a variety of phagocytes; enhances phagocytes activity
|
|
|
macrophage migration inhibition factor
|
protein that prevents phagocytes from leaving the scene
|
|
|
5). d. suppressor T-cells
|
control cytotoxic T-cells
|
|
|
5). e. hypersensitivity
|
???
|
