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10 Cards in this Set
- Front
- Back
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what are the three types of effector T cells and what do they do?
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CD8 are cytotoxic T cells that lyse virus infected cells. CD4 TH1 cells activate macs to phagocytoze and kill bacs. CD4 TH2 cells activate B cells.
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T cells can only see antigens that are what?
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complexed with another cell's MHC
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what are the professional antigen presenting cells?
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dendritic cells, macs, and B cells
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MHC I's are found on which cells? MHC II cells are found on what cells?
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all nucleated cells. APC's including thymic epi
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what kinds of antigens are present on MHC I?
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endogenous antigen (eg from virus infection).
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what kind of antigen is present on MHC II?
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exogenous antigen processed through endosomes and from extracellular sources
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where do lymphocytes move from circulation intpo the lymph node?
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the post capillary venules AKA high endothelial venules
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what are the two signals required for T cell activation?
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epitope specefic: MHC + antigen/TCR
Co stimulatory signal: B7/CD28 |
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what is the key cytokine for T cell proliferation?
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IL-2
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what cytokine is needed to tell the differentiating T cell to become a TH2 cell? TH1?
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IL4. IFNgamma
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