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21 Cards in this Set

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Name 5 organelles

*Lysosomes


*Mitochondria


*ER (smooth and rough)


*Golgi


*Cytoskeleton


*Nucleus

Lysosome

'Digester of the cell'


Vesicles/sacs with enzymes that can break down macromolecules

Mitochondria

'PowerHouse of the cell'


Responsible for cell respiration. Source for ATP. Has own DNA

Endoplasmic Reticulum

Smooth ER - site of synthesis for lipids, phospholipids etc.


Rough ER - studded with ribosomes, translation of RNA to protein, vesicles bud off and transport to golgi apparatus

Golgi

'Recycler of Proteins in the cell'


Sorting of proteins for delivery to sites in need. (E.g. Recycling of neurotransmitters that have been broken down in the synapse)

Nucleus

'Controller of the cell'


Contains genetic material, DNA, in chromosomes.

Name features of a neuron

*Dendrites


*Soma (cell body)


*Cell nucleus


*Axon


*Myelin Sheath


*Node of Ranvier


*Axonal terminal

Describe the process of information being passed from neuron to neuron

1# Information received 'excitation' - from dendrites


2# Summation of excitation. Is it sufficient for action potential generation? - passing through soma


#3 Action potential generation (starts up) and propagated (transmits) - along axon


4# Information sent - at axon terminal

A Neuron's myelin sheath is formed by...?

In the CNS - Oligodendrocytes


In the PNS - Shwann cells

Define Action Potential. *What goes in and what comes out?

An electrical signal, generated by movement of charged ions moving through ion channels within the plasma membrane.


Sodium (Na+) goes IN


Potassium (K+) goes OUT

Describe the process of an Action Potential

1a. Excitation occurs. This is a depolarization of the membrane, which causes Na+ channels in the first part of the axon to open.


1b. Na+ ions flood into the axon causing further depolarization.


2a. Depolarization causes Na+ channels in the second part of the axon to open and Na+ ions to open here.


2b. In the first part of the axon Na+ channels close (inactivation) and K+ channels open - this is a slow response to the earlier depolarization.


3. This process continues along the axon. Inactivation of Na+ channels prevents the excitation flowing backwards.

What happens at the chemical synapse?

At the axonal terminal neurotransmitters are released by exocytosis. This is stimulated by depolarization of the plasma membrane by an action potential.

The answer contains 6 key words

What happens at the chemical synapse?

At the axonal terminal neurotransmitters are released by exocytosis. This is stimulated by depolarization of the plasma membrane by an action potential.

The answer contains 6 key words

Neurotransmitter: Glutamate


Is it EXCITATORY or INHIBITORY? What is its RECEPTOR(S)

Glutamate:


EXCITATORY


RECEPTOR(S) - AMPA, NMDA

Neurotransmitter: AcetylcholineIs it EXCITATORY or INHIBITORY? What is its RECEPTOR(S)

Acetylcholine:


EXCITATORY


RECEPTOR(S) - Nicotinic, Muscarinic

Neurotransmitter: SerotoninIs it EXCITATORY or INHIBITORY? What is its RECEPTOR(S)

Serotonin:


EXCITATORY


RECEPTOR(S) - 5HT 1-7

I am EXCITATORY and my receptors are D1-5


What am I?

Dopamine

I am EXCITATORY and my receptors are alpha and beta


What am I?

Adrenaline and Noradrenaline

Neurotransmitter: GABAIs it EXCITATORY or INHIBITORY? What is its RECEPTOR(S)

GABA:


INHIBITOR


RECEPTOR(S) -GABA a,b

I am INHIBITORY and my receptor is GlyR


What am I?

Glycine

Why are neurons susceptible to disease? Explain.

* Has a Complex Function:


- Huge range of genes involved.


* Has High Demands:


- Transports cargo over long distances


- High energy requirements


* Long lived


-Terminally differentiated, lasting entire lifetime


- Stress associated with ageing neurons (e.g. Mitochondria,degrading dysfunctional proteins)