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19 Cards in this Set
- Front
- Back
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Cell Cycle-Cyclin/CDK Complex
G1 Phase |
CDK4, CDK6/Cyclin D
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Cell Cycle-Cyclin/CDK Complex
G1 to S Transition |
CDK2/Cyclin E
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Cell Cycle-Cyclin/CDK Complex
S Phase |
CDK2/Cyclin A
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Cell Cycle-Cyclin/CDK Complex
S to G2 Transition |
CDK1/Cyclin A
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Cell Cycle-Cyclin/CDK Complex
G2 to M Transition |
CDK1/Cyclin B (MPF)
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M Phase=?
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Mitosis
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G1 Phase=
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Gap1=metabolically active/growing
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S Phase=
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Synthesis=DNA Synthesis (2n to 4n)
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G2 Phase=
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Gap 2=cell growth, preparation for mitosis
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G0=
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Quiescent State=stopped dividing, re-enter cell cycle in response to stimulus
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Terminally Differentiated
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exited cell cycle/no longer divides (neurons, muscles cells, leukocytes)
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Phases of Interphase
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G1, S, and G2
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How can you tell where a cell is in the cell cycle?
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the amount of DNA content.
G1<S<G2/M |
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What are cyclins? what do they do/regulate? what do they bind to? levels?
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cyclins are a family of proteins that control progression of cell thru the cell cycle.
Amount of certain cyclins fluctuates in diff phases of the cell cycle to regulate CDK, to which it binds. |
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what is CDK? function? levels?
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family of protein kinases that phophorylate broad range of proteins substrates to complete cell cycle. levels remain fairly stable through cell cycle.
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Cyclin levels _____ during ______ and ______ during ________
this flucuation of the formation of CDK/CYCLIN complexes regulates_____ |
increases during synthesis and decreases during degradation
regulates active CDK/cyclin complexes during cell cycle? |
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CAK
CDK Inhibitory kinases Cdc23 Family |
CDK-activating kinase-phosphorylates CDKs to FULLY active CDK/Cyclin Complex
-Phosphorylates CDKs on other, seperate AA to INHIBIT CDK/Cyclin Complex activity -Cdc25 REACTIVATES inhibited CDK/Cyclin complexes |
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CKI-what are they?
name the 2 important ones. |
cyclin dependent kinase inhibitors,-family of proteins that bind to CDK/Cyclin complex and inhibit activity
INK Family-p16=tumor suppressor gene-inhibits SPECIFICALLY CDK4, CDK6/Cyclin D, Blocks G1 Phase CKI= Cyclin-Kinase Inhibitors="Cyclin-Kipper Inking" KIPper is a 21 year old dog (dog years=p21) and there are lots of kipper books (broad range) the INK used to draw kipper is only 16 years old (p16) and runs out really quickly so you can only draw certain stuff Cip/Kip Family=p21=GENERAL/BROAD range of inhibition |
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What is the restriction point?
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decision point late in G1 phase. cell becomes committed to S phase entry and completion of cell cycle
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