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7 Cards in this Set
- Front
- Back
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Positive regulators of Cell Cycle
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Cyclins D, E, B, A
Cyclin dependent kinases 4, 2 CDC 25 A, B, C C-Myc |
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Negative Regulators of Cell Cycle
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Cyclin-dependent kinase inhibitors
p53, pRb, TGF-beta |
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Facilitators of Cell Cycle
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E2F family of proteins
C-Myc |
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Rb
Retinoblastoma |
Prevents excessive cell growth by inhibiting cell cycle
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pRB
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Prevents the cell from replicating dangerous DNA; G1>S; Binds and inhibits transcription factors of E2F family
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E2F-DP
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pushes cell into S cycle, if they are inactivated by pRB, cell remains in G1
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Myc + Max
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regulates the trascription of the promoter. Myc activation always requires Max
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