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9 Cards in this Set
- Front
- Back
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Lonafarnib drug treatment on progeria + Ras blocks FT-ase |
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Taxol chemo drug blocks Anaphase A depolymerization of MT on both sides |
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Colchicine chemo drug blocks Anaphase B by preventing polar MT polymerization |
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DM1 cytotoxic attachment to anti-receptor antibodies like in Herceptin "smart bomb therapy" |
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B-Raf drug Vemurafenib over time is insensitive due to Raf deleting that binding domain for it |
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Imatinib/Gleevac first drug targeting tumor-specific kinase C > T transition in 2nd codon of Threonines into isoleucines, preventing this drug from binding onto the Bcr-Abl kinase |
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PhIP potentially dangerous/carcinogenic substance in highly-cooked meat Guanine adducts create G > T transversion |
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benzo(a)pyrene potentially carcinogenic substance in cigerettes hypoxides (metabolic intermediate) create Guanine adducts which give G > T transversion |
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Aflatoxin B potentially carcinogenic substance found in the mold that grows on peanuts Guanine adduct, G >T transversion |
