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9 Cards in this Set
- Front
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- 3rd side (hint)
Enzymes steps
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Substrates enter active site; enzyme changes shape so its active site embraces the substrates (induced fit). Substrates held in active site by weak interactions, such as hydrogen bonds and ionic bonds Active site (and R groups of its amino acids). Substrates are Converted into Products. Products are Released.
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None
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The active site can lower an EA barrier by
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• acting as a template for substrate orientation, • stressing the substrates and stabilizing the transition state, • providing a favorable microenvironment, • participating directly in the catalytic reaction.
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None
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Cofactors
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Are non protein enzyme helpers Cofactors and are required for catalysis: May be bound to the enzyme permanently. E.g, zinc. iron
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None
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Coenzymes
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Are organic cofactors e.g vitamins
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Competitive inhibitors
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Bind to the active site of an enzyme, competing with the substrate
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Noncompetitive inhibitors
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Bind to another part of an enzyme, changing the function
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Allosteric regulation
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Is the term used to describe any case in which a protein’s function at one site is affected by binding of a regulatory molecule at another site
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Cooperativity
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A form of allosteric regulation that can amplify enzyme activity. When substrate bonds to the active site of one enzymatic subunit, the rest of the subunits are stimulated and become active.
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None
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Feedback Inhibition
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The end product of a metabolic pathway shuts down the pathway
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