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17 Cards in this Set
- Front
- Back
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What is constitutive transport?
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secretory vesicles from TGN go to the plasma membrane
-default pathway - flow is continuous -supplis PM with new lipids and proteins - no clathrin |
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When is constitutive transport used?
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To delivere proteoglycans and glycoproteins out of the cell
- fibronectin, collagen, albumin, transferrin |
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What is regulated secretion?
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Special secretory vesicles rely on rapid, signal-dependent release of hormones, neurotransmitters, digestive enzymes
-more common -needs an incoming signal |
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Which of the secretion methods is clathrin dependent?
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regulated secretion
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In which secretion is cargo concentrated?
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regulatory secretion
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Which secretion method gets away with serum albumin, transferrin in mammalian hepatocytes?
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constitutive secretion
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What types of cells use lots of regulated secretion?
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neurons, B-islet cells, mast cells, goblet cells, eggs, sperm, nerutrasmitters, insulin, histamine, mucin
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How much is stuff concentrated in regulated secretion?
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200 fold
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What is the signal for regulatory secretion?
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a patch, similar to m6P
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What type of ATPase does secretory secretion use and for what?
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V-type atpase for acidification
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Where do secretory vesicles chill out?
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In the cortical cytoplasm subjacent to the PM
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How are secretory vesicles moved?
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kinesin and mysin motors.
Microtuble and actin-dependent process |
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Which clathrin adaptor complex is used in regulated secretion?
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AP-1
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Why is proteolytic processing advantageous?
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cells can synthesize and package inactive pro-molecules that are activated after secretion.
-ie pro-insulin, digestive enzymes |
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In what substance are secretory vesicles enmeshed?
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actin-membrane cytoskeleton network.
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What happens after regulated exocytosis is bound by the cell surface?
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an intracellular signal like a rise in Ca levels.
-disruption of cortical cytoskeleton -movement of vesicle to PM where fusion and secretion occur |
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What are the two routes from TGN of protein sorting?
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direct pathway- TGN to PM domain
Indirect pathway - TGN to incorrect domain. Then transportation to correct via transcytosis. - basal membrane first. |
