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8 Cards in this Set
- Front
- Back
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How do materials get to the lysosome?
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-biosynthetic ER pathway
-Endocytic pathway -Autophagic -Phagocytic |
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How are lysosomal proteins transported from the TGN of the golgi?
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- hydolases use 2 signals
1. signal 3D patch read by glycosyltranferases i cis-G that add mannose 6-phosphate 2. Mannose 6 - phosphate marker is read by receptors in the trans G network Then the proteins are shipped out with Man-6-Phosp to the Golgi. |
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What ensures the acidit of a late Endosome/lysosome?
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an ATP H+ pump.
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Whjat is the scavenger pathway?
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-Lysosomeal proteins go to the PM first then are picked up by early endosome.
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What is the problem with Hurler;s?
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-glycosaminoglycans (ECM) proteins which should be taken up by fibroblasts, builds up
- doesnt have the right lysosomal enzyme - |
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How do you treat Hurler's?
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-introduce normal cell, which will secrete some needed hydrolase that got away.
- Scavenged using PM Mannose6-P receptors |
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What is I-cell disease?
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-No M6-P tag.
- no sorting and tragetting of huydrolases. |
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Why does the cell need endocytosis?
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-uptake of nutrients
-clear harmful substances -maintain surface-volume ratio |
