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15 Cards in this Set
- Front
- Back
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SRP
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signal recognition particle; has a binding site for the signal sequence of a growing polypeptide and for the ribosome
when SRP and SRP receptor protein bind together, a GTP binds to each to strengthen bond |
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localization to ER
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localization to ER
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-When SRP & the SRP receptor protein bind together, a GTP binds to each to strengthen the bond
-Hydrolysis of GTP causes transfer of polypeptide to translocation protein -After transfer, the 2nd GTP is hydrolyzed and the polypeptide is moved through the channel & SRP leaves |
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Localization to ER - Ribosome
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transmembrane localization
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transmembrane protein - multipass
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Secretory Pathway
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Proteins and lipids are transported via vesicles and modified before leaving the cell or going to other parts of the cell
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Endocytic pathway
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materials are brought into the cell via vesicles from the plasma membrane
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lysosome
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breaks down material in cell
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endosome
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'sorting center'
-vesicles from outside transported to endosome first to be sorted |
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clathrin
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-attach to adaptin on vesicle, coats vesicle (clathrin coat)
-later removed after vesicle fully formed (requires chaperons (ATP) and other proteins) -clathrin basket formation pulls membrane upward into vesicle -three-legged structure, "triskelion" |
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Dynamin
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-GTPase that uses GTP to pinch off vesicle
-2 conformations; GTP is hydrolyzed and proteins restrict around membrane until the phospholipids reorganize and pinch off |
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adaptin
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Binds between cargo receptor and clathrin of vesicle
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vesicle initiation
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cargo proteins bind to cargo receptors within membrane; clathrin basket formation pulls membrane upward
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Triskelion
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three-legged structure of clathrin
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