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18 Cards in this Set
- Front
- Back
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8 Categories of Actin-associated Proteins:
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1. Motor (myosin)
2. Cross-linking (filamin, a-actinin) 3. Linking (spectrin, dystrophin, vinculin) 4. Severing (coflin, gelsolin) 5. Monomer-binding (profilin, thymosin) 6. Capping (actin-capping protein) 7. Nucleation/polymerization (WASP, ARP) 8. Signaling (rho, rac, cdc42) |
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Microfilament functions
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1. support and organize plasma membrane
2. cell shape 3. cell division 4. cell motility |
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What are the 3 major categories of acting-targeted drugs?
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1. actin depolymerizing drugs (latrunculin, cytochalasins)
2. actin stabilizing drugs (phalloidn-death-cap mushroom) 3. singaling perturbants (phorbol esters (via PKC)) |
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Microtubule functions
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1. organize cytoplasm
2. motility 3.ciliary/flagellar motility 4.cell division |
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how does taxol work?
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stabilizes tubulin
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how do colchicine and colcemid work?
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depolymerize tubulin
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what drug depolymerizes tubulin?
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colchicine and colcemid
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what drug stabilizes tubulin and prevents it's depolymerization (freezes it)
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taxol
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what is taxol used for?
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cancer treatment, 'freezes' microtubules (tubulin) and disturbs spindle dynamics
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4 types of intermediate filaments
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1. keratins
2. vimentin-like 3. neurofilament 4. lamins |
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Where are the 4 types of intermediate filaments found?
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1. keratins-epithelia
2. vimentin-like- mesenchyme, muscle, glial cells 3. neurofilament-CNS & PNS neurons 4. lamins- nuclei of all cells |
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Which cellular filaments are directional?
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Microtubules & Actin
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What cellular filaments are not directional
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Intermediate filaments
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Desmosomes are composed of what fiber?
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Intermediate filaments
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Desmosomes connect?
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Cell-cell
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Hemidesmosomes connect?
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Cell-ECM
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Cell-cell desmosomes are what kind of protein?
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Cadherin (extracellular) & intermediate filaments (intracellular)
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Cell-ECM hemidesmosomes are what kind of protein?
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Integrin (extracellular) & intermediate filaments (intracellular)
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