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9 Cards in this Set
- Front
- Back
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What are 5 types of cell adhesion?
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Tight junction
Adherens junction Desmosome Hemidesmosome Gap junction |
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Describe tight junctions
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Forms an impermeable seal
Proteins - claudins and occludins |
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Describe adherens junctions
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Holds epithelial cells together
Uses cadherin which attaches to actin skeleton via linker proteins Allows for changes in cell shape to form vesicles, neural tube |
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Describe desmosomes
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Holds epithelial cells together
Uses cadherins which connect to intermediate keratin filaments |
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Describe hemidesmosomes
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Holds cells together
Attach keratin inside cell to laminin in basal lamina (ECM) via integrins |
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Decribe gap junctions
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Allows ions and small molecules to pass through
Uses connexons which form channels |
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Describe pemphigus
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Autoantibodies form against desmoglein which is a cadherin and is involved in forming desmosomes. Causes cells to separate
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How is a cell attached to collagen or ECM proteins?
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Fibronectin binds to collagen, integrins binds to fibronectin and spans membrane and binds to actin (cell cytoskeleton) in cell
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What happens to cell motility if they are bound too weakly/too strongly?
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Too weak - not enough traction between cells
Too strong - cells remain stationary |
