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50 Cards in this Set
- Front
- Back
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Mutation in CD 18 |
Leukocyte Adhesion Deficiency (LAD)
- No intergrins = no tight binding = increased circulating neutro's and no neutro's in inflammed tissue |
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Mutated NADPH oxidase |
Chronic Granulomatous Disease (CGD)
No resp. burst in Neutros -> recurrent bacterial/fungal ifxns |
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GM-CSF treated Neutro w/ Toxic Granulation
-"May-Hegglin Anomaly" = Dohle Bodies (RER remnant), large granules, vacuoles, L-shift |
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Toxic Degranulated Neutro due to sepsis
- Same as GM-CSF treated but have bacterial inclusions |
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Chediak-Higashi Syndrome
- recessive mutation causing abnormal degranulation w/ large aggregated inclusions, pancytopenia, and recurrent pyogenic ifxns |
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Mutated RAS |
Signal-transducer oncogene - causes no GTP hydrolysis = continual growth signals |
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Deletion of 17q |
Li-Fraumeni Syndrome
- inherit one mutation of p53 (detects DNA damage -> activates p21 to inhibit cycD/CDK4) * Increased risk of cancer |
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CD45 |
WBC |
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CD34 |
Stem Cell |
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CD2-8 |
T-Cell (Immature = Neg for 4 & 8, Int = Pos for 4 & 8, Mature = Pos for 4 or 8) |
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CD19 |
Immature and Mature B cells |
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CD 20 |
Mature B cells |
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CD38 |
Plasma Cells |
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CD16, 56 |
NK cells |
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CD 15, 13, 33 |
Myeloid |
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CD 61 |
Megakaryocyte |
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Glycophorin A |
Mature RBC |
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CD71 |
Transferrin on RBC |
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MPO+, SBB+, NSE+ CD117+ CD 13, 33+ |
Acute Myeloid Leukemia *CD117 = c-kitt that inhibits apoptosis |
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MPO-, TdT+ |
Acute Lymphoid Leukemia/Lymphoma |
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CD34+, HLA-DR+ |
Acute Promyelocytic Leukemia *EMERGENY all-trans retinoic acid administration! |
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t(17,15) Retionic acid receptor (RAR) |
Acute Promyelocytic Leukemia
Blocks maturation causing Faggot Cells w/ Auer Rods to form sheets of cell -> degranulate to cause DIC! |
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t(8, 21) ETO |
AML w/ Neutrophil Maturation
Good prog |
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Inversion of CBFB and MYH11 genes on Chr 16 |
AML w/ Monocyte and Granulocyte Matuation
*Abnormal eosinophils in BM
Good prog |
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t(1, 22) and no MPO expression |
Acute Megakaryoblastic Leukemia *Poor prog, seen in kids/infants -- especially Down's kids < 5 |
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NPM1 mutation |
1/3 of AML's -- indicate good prognosis unless that also have FLT3-ITD mutation |
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TdT+ CD 10, 19, 20+ |
B-ALL |
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t(12,21) Hyperdiploid |
B-ALL w/ good prognosis (TEL/AML) |
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t(9, 22), Hypodiploid p190 |
B-ALL w/ poor prognosis
- BCL-R/ABL fusion protiein that increases Tyr kinase activity |
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TdT+ CD 2-8+ CD10- |
T-ALL |
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t(9, 22) p210 breakpoint point protein |
"Philidelphia Chromosome" - CML
*BCR-ABL fusion protein that increases Tyr kinase activity |
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JAK2 Kinase mutation |
50% Myelofibrosis (rest are CALR mutants), 50%Essential Thrombocythemia, 95% Polycythemia Vera |
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KITT mutation |
Mastocytosis (type of MPN) |
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5q deletion |
Myelodysplastic Syndrome w/ increased plts and macrocytic anemia seen in elderly females |
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CD45+, CD10+ CD 15-, CD 30- |
Non-Classical Hodgekin Lymphoma = Nodular Lymphocyte Predominant
*L & H cells |
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CD45-, CD10- CD15+, CD30+ |
Classical Hodgekin Lymphoma (Nodular Sclerosis, Mixed Cellularity, Lympho-Predom, Lympho-Depleted)
*Painless supradiagphragmatic LAD, Reed-Sternberg cells |
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BCL-2+, CD10+ |
Follicular Lymphoma (Low Grade, Stage IV) |
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t(14, 18) |
BCL-2 to Ig heavy chain Follicular Lymphoma (Low grade, Stage IV) |
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t(14, 8) |
c-myc to Ig Heavy Chain Burkitt's Lymphoma (High grade) |
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"Starry Sky" sheet of cells that are BCL-2 negative |
Burkitt's Lymphoma (High Grade) |
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t(14, 11) |
Cyclin D1 to Ig Heavy chain Mantle Cell Lymphoma |
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Naive B cells co-expressing CD5+ and CD20+ |
CLL |
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t(2, 5) Horseshoe-nucleus cells +ALK |
Anaplastic Large T Cell Lymphoma |
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Proliferation of clonal light chain memory B cells especially in MALT |
Marginal Zone Lymphoma |
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Pautier Microabcess (CD4+ proliferation in epidermis) |
Mycosis Fungoides |
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Skin CD4+ lymphoma with spread to blood w/ popcorn like cells |
Sezary Syndrome in Mycosis Fungoides |
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CD4+ Proliferation w/ Hepatospleenomegaly, hypercalcemia w/ lytic bone, flower cells |
Adult T Cell Leukemia/Lymphoma |
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+S-100a, CD1a, Langerhan |
Langerhan's Cell Histocytosis |
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Birbeck (tennis Racket) granules and skull lytic leisons |
Langerhan's Cell Histocytosis |
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Many translocations that all result in upregulation of Cyclin D |
MGUS, Solitary Plasmacytoma, Multiple Myeloma |
