Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
19 Cards in this Set
- Front
- Back
|
ECM component
|
ground substance
fibers |
|
|
ground substance components
|
GAG
proteoglycans |
|
|
glycosaminoglycans consist of:
|
large, unbranched polysaccharides
usually sulfated except hyaluronic acid |
|
|
what is the territorial matrix, and how does it stain w/ H&E
|
lacunae where chondrocytes reside
basophillic |
|
|
proteoglycans consist of:
|
inner protein core studded w/ GAGs
contribute strength to ECM hydrated to maintain gel-like state of ECM |
|
|
Hashimoto's symptoms
|
hypothyrodism from autoimmune
goiter facial myxedema memory loss, fatigue |
|
|
Grave's symptoms
|
hyperthyroidism
goiter pretibial myxedema weight loss, high body temp, nervousness |
|
|
ECM fibrous components
|
collagen
reticular fibers elastic fibers |
|
|
Two types of collagen
|
fibrillar (I, II, III)
non-fibrillar (IV, VIII) |
|
|
Type I collagen stain w/ H&E
|
eosinophilic
|
|
|
Collagen synthesis
|
preprocollagen synthesized in RER
preprocollagen hydroxylated at pro and lys residues 3 proprocollagen -> triple helix -> single procollagen procollagen glycosylated -> RER -> Golgi -> exported procollagen peptidases -> form tropocollagen tropocollagen spontaneously aligns end to end to form fibrils |
|
|
collagen fibril banding pattern width
|
67nm
|
|
|
osteogenesis imperteca
|
1:20,000 births
weak bones genetic defect in collagen gene(s) "brittle bone syndrome" |
|
|
reticular fibers
|
actually type III collagen
most delicate 20nm diameter component of basement membrane, stroma of lymphatics |
|
|
reticular fiber staining
|
doesn't stain w/ H&E
stains w/ silver (long thin strands) |
|
|
elastic fibers
|
inner ELASTIN (protein) core studded w/ microfibrils (fibrillin)
commonly found in: - walls of large arteries - elastic cartilage |
|
|
elastic fiber staining
|
doesn't stain w/ H&E
stains w/ elastic stain |
|
|
metallo matrix proteases
|
Ca, Zn, Cu dependent
facilitate migrating through ECM clinically important in metastatic disease |
|
|
what inhibits MMPs
|
tissue inhibitors of matrix metalloproteases (TIMPs)
|
