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25 Cards in this Set
- Front
- Back
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the definition of pH dependent on H+ ion activity in a given solution is?
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pH = -log(aH+)
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the -log(aH+) is equal to the -log of what two values?
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1. the H+ ion activity coefficient
2. The H+ ion concentration |
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what is the normal pH of blood plasma in the body?
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7.4
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what concentration of free H+ ions is this?
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50 nM
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what are the two types of acids or bases?
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1. Volatile
2. Nonvolatile |
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define a volitile acid or base?
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have gaseous components with which they are in equilibrium with
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what are the two types of nonvolitile acids or bases?
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organic and inorganic
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what concentration of volitile acid, CO2, does the body produce per day?
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14 moles per day
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what is the total concentration of nonvolitile acids produced in the body per day?
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60 millimoles per day
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all nonvolitile acids or bases are removed from the body by which organ?
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the kidneys
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the most produced volitile acid in the body is excreted by which organ?
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the lungs = CO2
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a proton donor is a?
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acid
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a proton acceptor is a?
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base
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what allows for the property of buffering in a solution?
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protons ability to reversibly bind many different substances
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How is disolved PCO2 calculated?
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PCO2 x solubility
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describe the Ka' for disolved CO2 in the blood?
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Ka' = ([HCO3-][H+]) / (dissolved CO2*)
* = PCO@ x solubility coefficient |
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what is the typical Ka' for dissolved CO2?
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10 to the -6.1
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what is [HCO3-] normaly in blood plasma?
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24 mM
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what is PCO2 in normal blood plasma?
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40 mmHG
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what is the solubility coefficient for CO2?
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.03 mM/mmHg
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how do weak acids and bases act as buffers?
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the react with free protons and thus minimize pH differences
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what is the equation for determining buffering power for a given vase or acid?
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buffering power = the amount of base added divided by the resulting change in pH
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what are the two major determinants of the effectiveness of a closed buffer?
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1. its concentration
2. the proximity of its pK' to the pH of the solution |
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when is a closed buffers buffering power at a maximum?
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when pH = pKa'
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the buffering power of a closed buffer is directly proportional to?
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its concentration
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