Case 2 Pharm Ch45

Front 1

Activation of the cAMP levels in a parietal cell happens when histamine binds and this activates movement of ___ from the cell into the lumen

Back 1

H+

Front 2

Aside from histamine ___ and ___ also increase H+ secretion by parietal cells

Back 2

Gastrin, ACh

Front 3

Somatostatin-secreting D cells and Prostaglandins stimulate/Inhibit Gastric Acid secretion

Back 3

Inhibit

Front 4

Protective Factors of the stomach (4)

Back 4

Mucus. Bicarb, Restitution (Repair), Blood Flow

Front 5

The major shitty part about H. Pylori is the ____ which alkalinizes the environment as well as causes a strong immune response

Back 5

UREASE

Front 6

Most NSAID's are weak organic acids/bases

Back 6

Acids

This allows them to cross the plasma membranes of gastric epithelia because they are active in the acidic environment

Front 7

NSAID's that inhibit COX-1/2 caan lead to mucosal ulcers because inhibition of PGE2 synthesis removes a protective mechanism

Back 7

COX-1!!!!

Front 8

Gastrin Secreting tumor of the pancreas

Back 8

Zollinger-Ellison Syndrome

Front 9

Ulcers in patients with increased vagal tone

Back 9

Cushing's ulcers

Front 10

Are H2 receptor antagonists reversible?

Back 10

Yes

Front 11

Why wouldn't you let a breast feeding momma take cimetidine

Back 11

It crosses the placenta and is secreted in the breast milk

Front 12

What are all the -zole drugs? (Omeprazole, esomeprazole, rabeprazole)

Back 12

Proton Pump Inhibitors!

Front 13

In order for a proton pump inhibitor to be activated they must

Back 13

be in the acidic environment of the parietal cell canaliculus

Front 14

The active form of all the proton pump inhibitors is called

Back 14

Sulfenamide

It binds IRREVERSIBLY

Front 15

H2 receptor antagonists are safe/aren't safe for pregnancy

Back 15

Are safe

Front 16

What's better for treating NSAID induced ulcers - Prot pump inhibitors or H2 receptor antagonists

Back 16

Proton Pump Inhibitors

Front 17

Four of the 5 proton pump inhibitors are metabolized by the liver which are they? (LIVERPOLE)

Back 17

Pantoprazole (Least extensively metabolized), Omeprazole (Most extensively metabolized), Lansoprazole, Esomeprazole

Rabeprazole is not

Front 18

Prot Pump inhibitors safe/unsafe for pregnancy

Back 18

UNSAFE DONT DO IT

Front 19

An anticholinergic that antagonizes muscarinic ACh receptors and thereby decreases gastric acid secretion

Back 19

Dicyclomide

Front 20

Name two antacids

Back 20

Magnesium and Alluminum hydroxide

Front 21

Patients with kidney disease should avoid _____- containing antacids

Back 21

Magnesium

Front 22

This coating Agent forms a gel that protects the luminal surface of the stomach from degradation by acid and pepsin

Back 22

Sucralfate

Front 23

This coating agent combines with mucus glycoproteins to form a barrier that protects an ulcer from further damage

Back 23

Colloidal Bismuth

Front 24

This drug is a prostaglandin analogue that is used in NSAID induced peptic ulcers

Back 24

MisoPROSTol

Front 25

Name the three components for Triple therapy when treating H. Pylori

Back 25

Antibiotics and a proton pump inhibitor

Amoxicillin, clarithromycin, and a proton pump inhibitor

Front 26

Serious adverse effect of cimetidine/h2 receptor antagonists

Back 26

Necrotizing enterocolitis in fetus or newborn.

Front 27

Adverse effect of Prot. Pump Inhib's

Back 27

Pancreatitis Hepatotoxicity, Interstitial Nephritis