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27 Cards in this Set
- Front
- Back
Activation of the cAMP levels in a parietal cell happens when histamine binds and this activates movement of ___ from the cell into the lumen
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H+
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Aside from histamine ___ and ___ also increase H+ secretion by parietal cells
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Gastrin, ACh
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Somatostatin-secreting D cells and Prostaglandins stimulate/Inhibit Gastric Acid secretion
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Inhibit
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Protective Factors of the stomach (4)
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Mucus. Bicarb, Restitution (Repair), Blood Flow
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The major shitty part about H. Pylori is the ____ which alkalinizes the environment as well as causes a strong immune response
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UREASE
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Most NSAID's are weak organic acids/bases
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Acids
This allows them to cross the plasma membranes of gastric epithelia because they are active in the acidic environment |
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NSAID's that inhibit COX-1/2 caan lead to mucosal ulcers because inhibition of PGE2 synthesis removes a protective mechanism
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COX-1!!!!
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Gastrin Secreting tumor of the pancreas
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Zollinger-Ellison Syndrome
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Ulcers in patients with increased vagal tone
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Cushing's ulcers
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Are H2 receptor antagonists reversible?
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Yes
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Why wouldn't you let a breast feeding momma take cimetidine
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It crosses the placenta and is secreted in the breast milk
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What are all the -zole drugs? (Omeprazole, esomeprazole, rabeprazole)
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Proton Pump Inhibitors!
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In order for a proton pump inhibitor to be activated they must
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be in the acidic environment of the parietal cell canaliculus
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The active form of all the proton pump inhibitors is called
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Sulfenamide
It binds IRREVERSIBLY |
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H2 receptor antagonists are safe/aren't safe for pregnancy
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Are safe
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What's better for treating NSAID induced ulcers - Prot pump inhibitors or H2 receptor antagonists
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Proton Pump Inhibitors
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Four of the 5 proton pump inhibitors are metabolized by the liver which are they? (LIVERPOLE)
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Pantoprazole (Least extensively metabolized), Omeprazole (Most extensively metabolized), Lansoprazole, Esomeprazole
Rabeprazole is not |
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Prot Pump inhibitors safe/unsafe for pregnancy
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UNSAFE DONT DO IT
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An anticholinergic that antagonizes muscarinic ACh receptors and thereby decreases gastric acid secretion
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Dicyclomide
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Name two antacids
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Magnesium and Alluminum hydroxide
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Patients with kidney disease should avoid _____- containing antacids
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Magnesium
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This coating Agent forms a gel that protects the luminal surface of the stomach from degradation by acid and pepsin
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Sucralfate
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This coating agent combines with mucus glycoproteins to form a barrier that protects an ulcer from further damage
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Colloidal Bismuth
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This drug is a prostaglandin analogue that is used in NSAID induced peptic ulcers
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MisoPROSTol
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Name the three components for Triple therapy when treating H. Pylori
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Antibiotics and a proton pump inhibitor
Amoxicillin, clarithromycin, and a proton pump inhibitor |
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Serious adverse effect of cimetidine/h2 receptor antagonists
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Necrotizing enterocolitis in fetus or newborn.
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Adverse effect of Prot. Pump Inhib's
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Pancreatitis Hepatotoxicity, Interstitial Nephritis
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