Case 2 Pharm Ch42

Front 1

______ catalyzes decarboxylation of histidine to histamine

Back 1

Histidine decarboxylase

Front 2

In what cells is histamine made

Back 2

Enterochromaffin-like cells

Front 3

Histamine causes bronchial smooth muscle constriction/dilation?

Back 3

Constriction

Front 4

Most prominent effect of histamine on the vasculature is __

Back 4

Dilation of the postcapillary venule bed

Front 5

Histamine induces/suppresses gastric acid secretion

Back 5

Induces - causes Ca2+ influx into parietal cells

Front 6

Activation of the H1 receptor leads to increase in levels of what

Back 6

IP3, DAG

THIS IS THE ALLERGIC TYPE OF HISTAMINE RECEPTOR
IP3 triggers release of Ca2+
DAG activates protein kinase C

Front 7

H1 receptors found in (3)

Back 7

Brain, Vascular Endothelium, Smooth Muscle

Front 8

Major functinon of H2 receptors is to

Back 8

Mediate Gastric acid secretion

Front 9

H3 receptor function to provide

Back 9

Feedback inhibition

Decrease Calcium influx

Front 10

H4 receptors are localized to ___ cells and lead to decreased cAMP

Back 10

Hematopoietic cells

Front 11

Can mast cell degranulation occur as a response to a local tissue damage?

Back 11

Fuckin right

Front 12

3 strategies of histamine pharm. Name the example drugs
1. Administer inverse agonists, or competetive antagonists of histamine receptor - For Allergies

Back 12

Diphenhydramine

Front 13

2. Prevent Mast cell degranulation - Asthma

Back 13

Cromolyn, Nedocromil

Front 14

3. Administer physiologic antagonists to counter the pathologic effects of histamine - Anaphylaxis

Back 14

Epinephrine

Front 15

First/Second generation H1 antihistamines are neutral at physiologic pH and readily cross the BBB

Back 15

First

Front 16

First/Second generation H1 antihistamines are ionized at physiologic pH and don't cross the BBB

Back 16

Second
(Loratadine, Ceterizine, Fexofanadine)

Front 17

Two dx's that H1 antihistamines aren't effective for

Back 17

Urticarial vasculitis, hereditary angiodema

Front 18

H1 antihistamines should not be used as the sole therapy for

Back 18

Asthma

Front 19

H1 antihistamines reach peak plasma concentration in _ to _ hours and are metabolized by the...

Back 19

2-3,, liver

Front 20

____ a second gen. H1 antihist is metabolized by P450 into an active metabolite so inhibitors of P450 can affect the metabolism of it

Back 20

Loratadine

Front 21

Along with the fact that second gen H1 antihist's are ionized at phys. pH, what is another reason they don't readily cross the BBB?

Back 21

The exhibit high binding to albumin and are thus less free to diffuse into the CNS

Front 22

Two of the most commonly used H2 receptor antagonists

Back 22

Cimetidine and Ranitidine

Front 23

Common adverse effect of Cimetidine the H2 receptor antagonist

Back 23

Inhibits Cytochrome P450 mediated drug metabolism

Front 24

H3 receptor antagonists induce what

Back 24

Wakefulness

Front 25

Diphenhydramine

Back 25

First gen. H1 antihistamine

Front 26

Pyrilamine

Back 26

First gen. H1 antihistamine

Front 27

Doxepin

Back 27

First gen. H1 antihistamine (tricyclic antidepressant for sad people)

Front 28

Chlorpheniramine

Back 28

First gen. H1 antihistamine

Front 29

Promethazine

Back 29

First gen. H1 antihistamine

Front 30

Hydroxyzine

Back 30

First gen. H1 antihistamine

Front 31

Citerizine

Back 31

2nd Gen. H1 Antihistamine

Front 32

Acrivastine

Back 32

2nd Gen. H1 Antihistamine2nd Gen. H1 Antihistamine

Front 33

Azelastine

Back 33

2nd Gen. H1 Antihistamine

Front 34

Anything that ends in -dine

Back 34

2nd Gen. H1 Antihistamine

Front 35

Cimetidine, Famotidine, Nizatidine, Ranitidine

Back 35

H2 receptor antagonist