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14 Cards in this Set
- Front
- Back
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what does ANCA stand for?
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antinuclear cytoplasmic antibodies
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where are the antigens for ANCA's found? (2 places)
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1. cytoplasmic granules of neutrophils
2. monocyte lysosomes |
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what are the two staining patterns for ANCE?
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1. cytoplasmic or "cANCA"
2. perinuclear or "pANCA" |
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by what mechanism do ANCA's cause local ischemia?
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they attack cytoplasmic granules in neutrophils causing them initiate inflammation in vessels which causes weakened walls with bleeding or aneurysm formation and intimal proliferation leading to thrombosis
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cANCA antibodies main antigen is?
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proteinase 3
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pANCA antibodies are mainly to what antigen?
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myeloperoxidase
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what is the most common fom of clinical vasculitis?
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hypersensitivity angiitis
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where is hypersensitivity angiitis most commonly found?
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skin and small vessels
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what are the vessels which are effected by hypersensitivity angiitis?
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venules
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Palpable Purpura is most likely associated with what vascular disease unless proven otherwise?
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hypersensitivity angiitis
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palpable purpura with a rash on the extensor surface of upper extremities is likely do to what disease?
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Rocky Mountain Spotted Fever
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serum sickness is a subset of which vascular disease?
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hypersensitivity angiitis
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what increases vessel wall permeability in serum sickness?
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vasoactive amines
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what is the chemotactic response generated in serum sickness?
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compliment is activated by the deposition of immune complexes on vessel walls and as a result C5 is produced with is a potent chemotactic agent for neutrophils
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