Cardiovascular Meds

Front 1

Ace inhibitors

Back 1

"-opril"

MOA:
1) stop conversion of AT-1 to AT-2
2) vasodilation and venodilation
decrease preload and afterload
balanced dilation
3) prevent inh of bradykinin (a potent vasodilator)

uses: HTN, decrease mortality in CHF
decrease proteinuria in diabetic neuropathy

S/E:
Cough
Angioedema/ Acidosis (metabolic)
Proteinuria
Taste changes
hypOtn (esp. unique is "1st dose hypotension")
CI in Pregnancy
Rash
Itching (2/2 increase bradykinin), Interstitial nephritis
Low AT- 2 & GFR
*"CAPTOPRIL"

CI: preggos (causes fetal renal agenesis), bilateral renal artery stenosis
Monitor:
1) Cr levels (dont want Cr levels to rise >30%)
2) BP: for hypOtn

Front 2

ARB's

Back 2

"-artans"

MOA:

uses: HTN

S/E: no itching (no bradykinin), no coughing (no sulfur), DOES CAUSE ANGIOEDEMA; DO NOT USE IN PREGNANCY

***Candisartan is the only ARB that DOES NOT cause angioedema

Front 3

Do ARB's cause
1) cough
2) angioedema
3) itching

Back 3

cough- no (dont contain sulfur)
angioedema- yes
itching- no (dont inc bradykinin)

Front 4

Mgmnt of AAA

Back 4

<4cm: 1st labatolol, 2nd nitroprusside
>6cm: surgery
4-6cm: dr's choice

Front 5

Mgmnt of thoracic aneurysms

Back 5

Type A- control HTN, surgery
Type B- control HTN, pray! (canNOT do surgery bc type b is us 2/2 co-morbidities that make this pt a poor surgical canditate)

Front 6

Examples of Renin inhibitors
-what organ do they work in?
-toxicity?

Back 6

"-kiren"
work in liver
#1 hepatotoxic drug

Front 7

Why do ACE-Inh cause cough, and ARB's dont?

Back 7

ACE- increase bradykinin (inh breakdown bradykinin)

Front 8

rx for prinzmetals

Back 8

Ca Ch blkrs or nitrates