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87 Cards in this Set

  • Front
  • Back
HCTZ?
Diuretic
Loop Diuretic?
Diuretic
Clonidine?
Sympathoplegic
Methyldopa?
Sympathoplegic
Hexamethonium?
Sympathoplegic
Reserpine?
Sympathoplegic
Guanethidein?
Sympathoplegic
Prazosin?
Sympathoplegic
BB?
Sympathoplegic
Hydralazine?
Vasodilator
Minoxidil?
Vasodilator
Nifedipine?
Vasodilator
Verapamil?
Vasodilator?
Nitroprusside?
Vasodilator?
Captopril?
ACEI
Enalapril?
ACEI
Fosinopril?
ACEI
Losartan?
ARB
Hypokalemia, slight hyperlipidemia, hyperuricemia, lassitude, hypercalcemia, hyperglycemia
HCTZ
Potassium wasting, metabolic alkalosis, hypotension, ototoxicity
Loop Diuretic
Dry mouth, sedation, severe rebound hypotension
Clonidine
Sedation, positive Coomb's test
Methyldopa
Severe orthostatic hypotension, blurred vision, constipation, sexual dysfunction
Hexamethonium
Sedation, depression, nasal stuffiness, diarrhea
Reserpine
Orthostatic and excercise hypotension, dizziness, HA
Guanethidine
1st dose orthostatic hypotension, dizziness, HA
Prazosin
Impotence, asthma, cardiovascular effects, CNS effects (sedation, sleep alterations)
BB
Nausea, HA, lupus-like syndrome, reflex tachycardia, angina, salt retention
Hydralazine
Hypertrichosis, pericardial effusion, relfex tachycardia, angina, salt retention
Minoxidil
Dizziness, flushing, constipation, nausea
Nifedipine, verapamil
Cyanide Toxicity
Nitroprusside
Hyperkalemia, Cough, Angioedemia, Proteinuria, Taste Changes, Hypotension, Pregnancy Problems (Fetal Renal Damage), Rash, Increased Renin, Lower Angiotension II
ACEI
Feta renal toxicity, hyperkalemia
ARB
First line drug for HTN in pregnancay along with methyldopa?
Hydralazine
What are the 2 types of Ca-channel blockers?
Dihydropyridine, Non-Dihydropyridine
Mech of dihydropyridine?
Selective for calcium channels in vascular smooth muscle.
Mech of nondihydropyridine?
Selective for calcium channels in myocardium.
Dihydropyridine drugs?
Nifedipine, Nicardipine, Amlodipine, Nisoldipine
Non-dihydropyridine drugs?
Diltiazem, Verapamil
Monday disease occurs with which drug?
Nitroglycerin, isosorbide dinitrate
How do BB increase coronary blood flow?
Increased diastole
Lovastatin, Pravastatin, Simvastatin, Atorvastatin, mech?
HMG-CoA reductase inhibitors
Cholesytramine, colestipol, mech?
Bile acid resins
Ezetimibe, mech?
Cholesterol absorption blocker
Gemfibrozil, clofibrate, bezafibrate, fenofibrate, group?
Fibrates
Drug that causes the following side effects? Expensive, reversible increase LFTs, myositis.
HMG-CoA reductase inhibitors
Drug that causes the following side effects? Red, flushed face, which is decreased by aspirin or long-term use.
Niacin
Drug that causes the following side effect? Pts hate it, tastes bad and causes GI discomfort.
Bile acid resins
Greatest LDL lowering drug?
Statin
Greatest Increase in HDL?
Niacin
Greatest triglyceride lowering drug?
Fibrate
Calcium sensitizers?
Ryanodine
Digoxin half-life?
40 hours
Digoxin elimination?
Urinary excretion.
Digoxin clinical use?
CHF (Increased contractility)
AFib (Decreased conduction AV node and depression of SA node)
Digoxin EKG effects?
Increased PR
Decreased QT
Scooping of ST segement
T wave inversion
Digoxin side effects?
Increased PS: N/V/D blurry yellow vision (think of Van Gogh). Arrhythmia.
Digoxin Toxicities?
Increased renal failure (decreased excretion), hypokalemia (potentiates drug's effects), and quinidine (decrease digoxin clearance; displaces digoxin from tissue binding sites)
Digoxin antidote?
Slowly normalize K+, lidocaine, cardiac pacer, anti-dig Fab fragments
Class I Antiarrythimics?
Na channel blockers
Class II Antiarrythmics?
BB
Class III Antiarrythmics?
Various ion channels + BB
Class IV Antiarrythmics?
CCB
Class IA Antiarrythmics?
Queen Amy Proclaims Diso's Pyramid
Q=Quinidine
A=Amiodarone
P=Procainamide
D=Disopyramide
Class 1B Antiarrythmics?
Lidocaine, Mexiletine, Tocainide
Class 1C Antiarrythmics?
Flecainide, Encainide, Propafenone
Affects both atrial and ventricular arrythmias especially reentrant and ectopic supraventicular and ventricular tachycardia
Class 1A
Affect ischemic or depolarized Purkinjie and ventricular tissue. Useful in acute ventricular arrythmias (esp post-MI) and in digitalis-induced arrythmias.
Class 1B
Useful in V-tachs that progress to VF and in intractable SVT. Usually used only as last resort in refractory tachyarrythmias.
Class IC
The ONLY class of durgs that decreases the QT interval and thus decreases refractoriness.
Class 1B
What drug has following side effects? Cinchonism (HA, tinnitus, thrombocytopenia), Torsades de pointes due to increased QT interval
Quinidine
What drug has the following side effect? Reversible SLE like syndrome.
Procainamide
What drugs have the following side effects? Local anesthetic. CNS stimulation/depression, cardiovascular depression
Class 1B
What drug has following side effects? Proarrythmic, especially psot-MI (contraindicated). Significantly prolongs refractory period in AV node.
Class 1C
Only antiarrythmic that does not bind to an ion channel in the heart.
Class II
Best antiarrythmics to increase PR interval?
Class II
Class II antiarrythmic that is very short acting?
Esmolol
Class II antiarrythmic that can cause dyslipidemia?
Metoprolol
What are three things one must remember to check when using amiodarone?
PFTs, LFTs, and TFTs
When is it safe to use amiodarone?
WPW Syndrome
Which drug has the following side effects? Pulmonary fibrosis, corneal deposits, hepatotoxicity, skin deposits resulting in photodermatitis, neurologic deficits, constipation, cardiovascular effects (brady, heart block, CHF), hypothyroidism/hyperthyroidism
Amiodarone
What class of drugs is used for the prevention of nodal arrythmias?
Class IV
Drug of choice in diagnosing/abolishing AV nodal arrythmias?
Adenosine
Depresses ectopic pacemakers, especially in digoxin toxicity.
K+
Effective in torsades de pointes and digoxin toxicity.
Mg+
Mech of Adenosine?
Increases potassium channel opening.
Advantage of adenosine?
Very short lived effects; given i.v.