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36 Cards in this Set
- Front
- Back
STEMI treatment algorithm (for symptoms LESS than 12 hours) (6)
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1)ASA & Nitro SL/IV
2)Clopidogrel 300mg 3)reperfusion therapy (PCI or fibrinolytics) 4)if using PCI follow w/ UFH, enox, GP2b/3a inhibitor 5)if using fibrinolytics follow w/ UFH, enox, fondaparinux 6)last step is put on BB, statins, ACEI/ARB, sprinonolactone |
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STEMI treatment algorithm (for symptoms MORE than 12 hours) (4)
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1)ASA/Nitro SL/IV
2)stress test/PCI/CABG 3)clopidogrel 4)finally BB, statin, ACEI/ARB, sprionolactone |
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Eptifibatide brand
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Integrillin
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Abciximab brand
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ReoPro
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Bivalirudin brand
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Angiomax
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Fondaparinus brand
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Arixtra
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Treatment of STEMI uses what drugs? (6)
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1)ASA
2)Nitro (morphine can be used on top of this for angina pain) 3)plavix 4)UFH, enoxaparin, fondaparinux 5)BB 6)thrombolytics |
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a)First generation thrombolytics
b)2nd generation thrombolytics c)3rd generation thrombolytics AND WHICH IS MOST FIBRIN SPECIFIC |
a)streptokinase
b)alteplase c1)reteplase***** c2)tenecteplase***** |
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Typical QUALITY (desc) features of angina due to CAD (7)
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1)discomfort (rather than pain)
2)crushing/pressure 3)squeezing 4)strangling 5)heaviness on chest 6)burning 7)NOT sharp or stabbing |
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Typical LOCATION features of angina due to CAD (5)
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1)retrosternal
2)visceral 3)across chest 4)diffuse 5)sometimes jaw, neck, arms only |
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Typical RADIATION features of angina due to CAD (6)
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1)to left shoulder or arm (CLASSIC)
2)sometimes right arm or both arms 3)neck, jaw, teeth 4)back 5)epigastrium 6)NOT below umbilicus or on top of head |
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Typical DURATION features of angina due to CAD (3)
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1)30sec to 30min
2)waxing and waning 3)NOT continuous for hours |
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Typical PRECIPITATING FACTORS features of angina due to CAD (4)
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1)exercise/exertion
2)emotional stress 3)cold weather 4)ANYTHING that increases oxygen demand |
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Typical RELIEVING FACTORS features of angina due to CAD (4)
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1)rest
2)nitro 3)ANYTHING that reduces cardiac workload 4)NOT antacids, NSAIDs or change in position |
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ABSOLUTE CI to thrombolytics (7)
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1)intracranial hemorrhage
2)known cerebral vascular lesions 3)known intracranial neoplasm 4)ischemic stroke within 3 months 5)suspected aortic dissection 6)Active bleeding or bleeding diathesis 7)significant closed head or facial trauma within 3 months |
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RELATIVE CI to fibronilytics (9)
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1)uncontrolled HTN
2)ischemic stroke (greater than 3months ago) 3)dementia 4)traumatic/prolonged CPR 5)major surgery less than 3wks ago 6)recent (2-4wks) internal bleed 7)pregnancy 8)active peptic ulcer 9)current warfarin use |
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Componenets of TIMI risk score (6)
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1)over 65yo
2)more than 3 coronary risk factors 4)ST-segment deviation 5)more than 2 angina events within 24hrs 6)use of ASA within 7 days 7)elevated cardiac markers |
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Risk according to TIMI score (3)
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1)0-2 low risk
2)3-4 intermediate risk 3)5-7 high risk |
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Management strategies of unstable angina/NSTEMI (2)
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1)early invasive strategy
2)early conservative strategy |
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Early invasive strategy (4)
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1)Cardiac cath done in order to....
2)perform a PCI w/o first getting... 3)a noninvasive stress test OR 4)w/o failing medical treatment |
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Early conservative strategy (6)
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0)medically manage ACS w/ antiplatelet & anti-coag
1)cardiac cath performed ONLY if... 2)persistent or recurrent chest pain 3)depressed LV fxn 4)malignant ventricular arrhythmia 5)high-risk physiologic stress test (+ on it) |
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Drugs used to treat unstable angina/NSTEMI (9)
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1)ASA/plavix
2)nitro SL/IV 3)UFH/enox/fondaparinux 4)bivalirudin 5)GP2b/3a inhibitor 6)BB 7)statins 8)ACEI/ARB 9)sprionolactone |
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Secondary prevention medications used to reduce long-term mortality (6)
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1)ASA
2)plavix 3)ACEI 4)aldosterone 5)BB 6)statins |
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How to treat PRIMARY IHD (9)
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1)lipid lowering therapy
2)HTN management 3)DM management 4)smoking cessation 5)antiplatelet therapy 6)Type A personality 7)post-menopausal 8)binge drinking (moderate drinking is NOT a RF) 9)diet/exercise |
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How to treat SECONDARY IHD (5)
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1)treat anginal/ischemic episode via Nitro
2)use anti-platelets 3)Maintenance of anginal pain symptoms (via BB (first line) or CCB (2nd) or long acting nitrates (3rd)) 4)Ranolazine for anti-ischemia 5)PLUS ABCDE APPROACH |
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Secondary intervention goals (2)
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1)prevent development of complications from MI (heart failure, arrhythmias, etc)
2)reduce symptoms of angina |
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Major CV risk factors by NCEP and JNC (9)
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1)smoking
2)HTN 3)low HDL (less than 40) 4)elevated TC and LDL 5)age (over 45men; over 55women) 6)family history of premature heart disease (1st degree male before 55; 1st degree female before 65) 7)inactivity 8)DM (this is considered an "equivalent" risk of an event as someone who has already developed IHD) 9)HDL over 60 is a NEGATIVE risk factor |
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CV effects of smoking (7)
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1)incr HR
2)incr BP 3)impaired O2 to heart b/c of carbon monoxide from smoke 4)negative inotrope 5)incr platelet adhesion 6)decr threshold for arrhythmias 7)impaired endothelial fxn |
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2 primary goals for treating pts @ risk for IHD (primary prevention)
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1)prevent pt development of IHD
2)modify pt risk factors for development of IHD |
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When should a pt @ risk for IHD get anti-platelet therapy?
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pt w/ 10year risk of a cardiac event if greater than 10%
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General treatment strategies for management of chronic stable angina (3)
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1)Nitro for acute ischemic attack
2)anti-platelets 3)BB, CCB, long acting nitrate for maintenance of anginal pain |
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ABCDE approach in SECONDARY IHD prevention
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A)anticoag, ACEI/ARB, anti-anginals
B)BB, BP C)cholesterol manage, cig smoking, cardiac revascularization D)DM, diet E)education, exercise |
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Nitro pt counsel points (6)
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1)keep in original container, tightly closed
2)Once SL nitro is opened, it is only good for 6months 3)Not addictive 4)take @ onset of chest pain 5)inadequate saliva may interfere w/ absorption of SL nitro 6)HA and sublingual tingling are common ADR's |
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Pharmacological effects of BB in secondary prevention of IHD (5)
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1)decr oxygen demand
2)decr HR, contractility, BP 3)incr wall tension 4)improves exercise duration 5)delays ST segment changes |
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Pharmacological effects of CCB in secondary prevention of IHD (6)
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1)vasodilation of arterioles and coronary arteries
2)decr arterial pressure 3)decr coronary vascular resistance 4)decr contractility 5)decr conduction velocity of SA/AV nodes 6)inhibits coronary artery vasospasm |
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Pharmacological effects of long acting nitrates in secondary prevention of IHD (4)
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1)decr oxygen demand by reducing venous return
2)dilates coronary arteries 3)incr oxygen supply due to vasodilation 4)inhibits vasospasm |