Cardio Metabolic Syndrome And Sleep Apnea

Front 1

5 categories of metabolic syndrome
(must have 3/5)

Back 1

obesity
high LDL
low HDL
elevated BP
elevated glucose

Front 2

result of visceral adiposity

Back 2

higher tissue volume of visceral fat = more insulin resistant

Front 3

adipokines secreted by adipocytes

Back 3

TNFa, IL-6, adiponectin, plasminogen activator, leptin

Front 4

TNFa

Back 4

directly affects insulin signalling by inhibitng tyrosine kinase phosphorylation of insulin receptor
stimulates lipolysis

Front 5

IL-6

Back 5

icreases circulating FFA
decreases adiponectin secretion

Front 6

Plaminogen activator inhibitor 1

Back 6

PAI-1 inhibits plasminogen activator
creates prothrombic milleu in body
acceleration of atherthrombosis
hyper coag

Front 7

Resistin

Back 7

increased in pts with insulin resist
decreases insulin sensitivity

Front 8

adiponectin

Back 8

low levels in metab synd pts
associated with MI
dec in pts with insulin resist
decreases TNFa and serum FFA

Front 9

Leptin

Back 9

regulates appetite
may increase insulin sensitivity

Front 10

Take Home point of visceral adipocytes:

Back 10

visceral more metabolically active
metabolic activity mediates insulin resistance: problematic

Front 11

normal vs abnormal skeletal muscle glucose disposal

Back 11

normal: tyr kin phos insulin receptor. then go thru PI3 kin to make a GLUT4 receptor: takes glucose out of circ and puts into skeletal muscle

abnormal: FFA and adipokines change tyr kin to ser/thre; reduces PI3, shunt to MAP kin. reduces GLUT4, pull less glucose out of circ

Front 12

SD-LDL

Back 12

more athergenic than LDL

Front 13

prediabetic

Back 13

people can have insensitivity to insulin for 10-12 years befor Dx of diabetes

Front 14

Metformin

Back 14

durg that increases insulin sensitivity

but lifestyle change is more important