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30 Cards in this Set

  • Front
  • Back
1. Inotropics cause ?
Have to do with muscle contractions: stonger contractions
Chronotropic drugs ?
Affect the rate of the heart
dromotropics affect?
dromotropics affect the electrical conduction
Name 3 class IV antidysrythmics?
class IV antidysrythmics are Calcium channel blockers:
so: Cardizem, verapamil, dilatezem, nifepidil
amlopidine
What makes Sotalol different?
Betapace or stalol is a non selective b blocker as it acts like a class III drug (inhibits repolarization) also acts like a class II (beta blocker)
Name a class III that would be used for life theratening ventricular tachycardia or ventricular fib?
Amiodarone and sotalol as well as ibutilide and dofetilide are all class III used for Ventricular tachycardia
What is the half life of amiodarone?
amidarone has a very long half life approching many days: therapeutic effect may linge after disconituation and may take up to 3 months for adverse effects to subside : so it is considered a last resort drug
Types of angina:
Stable AKA Exertional
goes away with rest
doesnt last more than 15 min.
Unstable angina
AKA Preinfarctional angina
needs nitro to go away
can happen at rest
35% have unstable will have an MI in next few years
Vaso Spastic Angina
Happens at rest
happens at a regular time
caused by a spasm of blood vessel
The three main therapeutic objectives of antianginals is:
1. minimize feq of attack/decrease pain
2. improve function
3. Prevent/delay an MI
Adverse Effects of Beta Blockers:
Bradycardia
Hypotensiion
impotence
altered glucose and lipid metab.
Dont Give Beta blockers if they have:
Asthma
hypotensive
bradycardia
glaucoma and head trauma
Name 4 B-Blockers:
atenolol
metoprolol
propranolol
nadolol
CCB's adverse effects are:
constipation
Hypertension
Normal state is?
Prehypertensive is?
Stage I is?
Stage II is?
normal : <120/<80
Prehypertensive: 120-130/80-89
Stage I: 140-149/90-99
Stage II >160/100
Categories of Antihypertensive Drugs:
Adrenergic
Angiotensin converting enzyme inhibis (ACE inhibs)
CCB's
Diuretics
Vasodialtors
Adrenergics: mechanism of action is?
stimulates Alpha receptors in the brain
that decreases nervous system stimulation and that cause a decrase in lood pressure
Methyldopa (Aldomet) is a ?
Adrenergic Centrally acting A2 receptor agonist
Clondine (Tenex) is a ?
Adrenergic HTN med. Centrally acting A2 Receptor Agonist
Methyldopa is the drug of choice for htn with what disease?
Pregnancy for methyldopa (aldomet)
Peripheral A1 blockers work on causing vaso dialation at the heart and blood vessels so it causes
Decreased Blood Pressure
Name 2 peripheral a2 blockers?
Cardura and Minipress are both peripheral a2 blockers
Clondine can be used for ????other than HTN?
used for nicotine withdrawl and opoid withdrawl
Adverse Effects of Adrenergics include?
Dry Mouth, Drowsiness, sedation constipation Headaches rash HIGH incidence of orthostatic hypotension constipation and sexual dysfunction
Never give Adrenergics to
asthmatics, kidney or liver disease, Maoi inhibitors
ACE inhibitors include:
catopril and lisinopril and they are different because?
CATOPRIL and Lisonpril are NOT PRO DRUGS...
Prodrugs is adrug that is _____ and must be ______ by the _______.
prodrug is inactive when given must be biotransformed by the liver
Lotensin, Capoten, vasotec, prnivil zestril, univasc, aceon, accupril, altace, mavic are all examples of ?
Ace inhibitors
Ace inhibitors are classified _____ preg category.
classified preg. category C and not for 1st trimester and D for 2nd and 3rd