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30 Cards in this Set
- Front
- Back
1. Inotropics cause ?
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Have to do with muscle contractions: stonger contractions
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Chronotropic drugs ?
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Affect the rate of the heart
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dromotropics affect?
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dromotropics affect the electrical conduction
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Name 3 class IV antidysrythmics?
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class IV antidysrythmics are Calcium channel blockers:
so: Cardizem, verapamil, dilatezem, nifepidil amlopidine |
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What makes Sotalol different?
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Betapace or stalol is a non selective b blocker as it acts like a class III drug (inhibits repolarization) also acts like a class II (beta blocker)
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Name a class III that would be used for life theratening ventricular tachycardia or ventricular fib?
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Amiodarone and sotalol as well as ibutilide and dofetilide are all class III used for Ventricular tachycardia
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What is the half life of amiodarone?
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amidarone has a very long half life approching many days: therapeutic effect may linge after disconituation and may take up to 3 months for adverse effects to subside : so it is considered a last resort drug
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Types of angina:
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Stable AKA Exertional
goes away with rest doesnt last more than 15 min. |
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Unstable angina
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AKA Preinfarctional angina
needs nitro to go away can happen at rest 35% have unstable will have an MI in next few years |
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Vaso Spastic Angina
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Happens at rest
happens at a regular time caused by a spasm of blood vessel |
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The three main therapeutic objectives of antianginals is:
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1. minimize feq of attack/decrease pain
2. improve function 3. Prevent/delay an MI |
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Adverse Effects of Beta Blockers:
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Bradycardia
Hypotensiion impotence altered glucose and lipid metab. |
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Dont Give Beta blockers if they have:
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Asthma
hypotensive bradycardia glaucoma and head trauma |
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Name 4 B-Blockers:
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atenolol
metoprolol propranolol nadolol |
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CCB's adverse effects are:
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constipation
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Hypertension
Normal state is? Prehypertensive is? Stage I is? Stage II is? |
normal : <120/<80
Prehypertensive: 120-130/80-89 Stage I: 140-149/90-99 Stage II >160/100 |
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Categories of Antihypertensive Drugs:
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Adrenergic
Angiotensin converting enzyme inhibis (ACE inhibs) CCB's Diuretics Vasodialtors |
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Adrenergics: mechanism of action is?
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stimulates Alpha receptors in the brain
that decreases nervous system stimulation and that cause a decrase in lood pressure |
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Methyldopa (Aldomet) is a ?
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Adrenergic Centrally acting A2 receptor agonist
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Clondine (Tenex) is a ?
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Adrenergic HTN med. Centrally acting A2 Receptor Agonist
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Methyldopa is the drug of choice for htn with what disease?
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Pregnancy for methyldopa (aldomet)
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Peripheral A1 blockers work on causing vaso dialation at the heart and blood vessels so it causes
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Decreased Blood Pressure
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Name 2 peripheral a2 blockers?
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Cardura and Minipress are both peripheral a2 blockers
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Clondine can be used for ????other than HTN?
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used for nicotine withdrawl and opoid withdrawl
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Adverse Effects of Adrenergics include?
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Dry Mouth, Drowsiness, sedation constipation Headaches rash HIGH incidence of orthostatic hypotension constipation and sexual dysfunction
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Never give Adrenergics to
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asthmatics, kidney or liver disease, Maoi inhibitors
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ACE inhibitors include:
catopril and lisinopril and they are different because? |
CATOPRIL and Lisonpril are NOT PRO DRUGS...
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Prodrugs is adrug that is _____ and must be ______ by the _______.
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prodrug is inactive when given must be biotransformed by the liver
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Lotensin, Capoten, vasotec, prnivil zestril, univasc, aceon, accupril, altace, mavic are all examples of ?
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Ace inhibitors
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Ace inhibitors are classified _____ preg category.
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classified preg. category C and not for 1st trimester and D for 2nd and 3rd
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