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12 Cards in this Set
- Front
- Back
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Name some common causes of increased CK (total).
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myocardial disease and injury, skeletal muscle disease and injury, hypothyroidism, malignant hyperthermia, prolonged hypothermia, cerebral injury, psycosis
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Myoglobin is rapidly released but not a cardiac damage specific marker. What is the normal range? Time course?
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Myoglobin (myo): males, 28-72 ng/mL; females, 25-58 ng/mL. Time to begin increasing 2-4 h; time to peak 5-12 h; return to normal 1-2 days
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TnT does not equal TnI but both are specific cardiac damgage markers. What is the normal range for TnT? Time course for TnT?
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Troponin T (cTnT): <0.03 ng/mL Time to increase 3-6 h; time to peak 12-28 h; return to normal ~2 weeks
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What is the normal range for TnI? Time course for TnI?
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Troponin I (cTnI): <0.1 ng/mL. Time to increase 3-6 h; time to peak 12-24 h; return to normal ~ 2weeks
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Creatine Kinase (CK) total measures the 3 isozymes catalytic activity but is not cardiac specific. What is the normal range of this marker? Time course?
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CK (total): males, 70-185 U/L; females, 45-145 U/L. Time to increase 3-8 h; time to peak 12-36 h; return to normal 1-4 d.
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Creatine Kinase - Myoglobin (mass) is a nonspecific marker. What is the normal range of this marker? Time course?
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CK-MB: <6 ng/mL. Time to increase 3-12 h; time to peak 12-24 h; return to normal 1-2 d.
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True/False - Troponin is specific marker and should not be detected in the serum of a cardiac healthy patient.
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True
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Name 3 ways in which Torponin I/T could be falsely positive or negative.
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Hemolysis, Fibrin, Heterophile ABs
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What are the physiologic effects of BNP secretion from ventricular myocytes stretch?
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inhibition of SNS; vasodilation; diuresis
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What is the role of NT-proBNP in clinical medicine?
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As a measure of ventricular stretch useful in diagnosing and staging CHF; differentate SOB from cardiac and non cardiac etiologies
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TDM, Therapeutic Drug Monitoring, is important for many reasons. Why with digoxin or CCBs?
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digoxin can cause nephrotoxicity and potassium dysfunction (Na/K ATPase); CCBs are metabolized by CYP450 isozyme CYP3A which is common polymorphism site.
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True/False - Cocaine, Cocaine with EtOH, and Amphetamines can all cause cardiovascular incidents through increased SNS.
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True
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