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9 Cards in this Set
- Front
- Back
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Carbapenems
Structure/Source? MoA? Susceptibility/Resistance? |
Synthetic B-Lactams (Sulfur Repl with Carbon on ring)
Moa: (Same as Penic/Cephalo) Bind PBP and blocks crosslinking/peptidoglycan synthesis Resistent to most B-Lactamase; Susceptible to carbpenemases |
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Carbapenem Coverage?
G+/-? DoC for? |
Good for B-Lactamase producing g+/g-/anaerobes/ Enterobacter/Pseudomonas
DoC for Enterobacter |
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Imipenem
Metabolism/Protection/Usage? Ae (1) |
(Carbapenem)
Rapidly degraded by Dihydropeptidase in Kidney, Needs Cisastatin to block dihydropeptidase; Ae: Seizures in 50% |
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Doripenem
Class? Spectrum? Excretion? What doesn't it cover? |
Carbapenem; Renal excretion
b-lactamase resistant g+/g-/anaerobes, pseudo DoC for Enterobacter No MRSA, |
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Entapenem
Class? Spectrum? Excretion? What doesn't it cover? |
Carbapenem; Renal excretion
b-lactamase resistant g+/g-/anaerobes, pseudo DoC-Enterobacter No MRSA, No Pseudomonas coverage |
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Meropenem
Class? Spectrum? Excretion? |
Carbapenem; Renal excretion
b-lactamase resistant g+/g-/anaerobes, pseudo DoC-Enterobacter No MRSA coverage |
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Carbapenem Pk
Route? Excretion? Cross-Allergy Reactions? |
Given IV or IM w/ lidocaine -irritates
Renal Excreted; Poss C-A-Rxn w/ penicillins |
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Monobactams
MoA? Resistance? Usage? IV vs IM coverage? |
Bind PBP and block cell wall synthesis (same as other b-lactams)
B-Lactamase Resistence, used for Ceph/Penicillin/carbapenem allergic PT's IV form only for g- rods (Hemoph/Enertobacteriaciae/Pseudo) |
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Aztreonam
Class? MoA? Usage? IV vs IM? |
Monobactam; same mech as penicillin
Used for Pen/Ceph/Carba Allergic PT's; B-lactamase resistent IV for g- rods only; |
