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9 Cards in this Set
- Front
- Back
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Carbapenems - drugs |
Imipenem/cilastatin Meropenem Ertapenem Doripenem
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Imipenem/cilastatin |
IV 500mg q6-8 hrs
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Meropenem |
IV 1 gm q 8hrs Febrile Neutropenia |
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Ertapenem |
IV 1gm daily Not for use with P. Aeruginosa |
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Doripenem |
IV |
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Carbapenems - Effective Against |
Effective against almost everything P. Aeruginosa, Bacteriodies, PPNG Static against C. Difficle |
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Carbapenems - Common Uses |
1. Serious Infections (highly resistant) almost everywhere 2. Septicemia 3. Febrile Neutropenia 4. Pseudomonas infx w/ aminoglycoside 5. High PCN resistant bugs |
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Carbapenems Facts |
1. Big Guns 2. Wide Vd, CSF Penetration 3. ADE: Hypersensitivity, Seizures, GI reactions (effects microflora) 4. Broken down by Metalo-beta-lactamases 5. Resistance - carbapenemases, and reduce porin size. 6. Really cleared so reduce dose |
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cilastatin |
inhibits imipenem hyrdolysis into toxic metabolite in kidney |
