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50 Cards in this Set
- Front
- Back
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which vin is not myelosuppresive
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vincristine (otherwise, it causes the bad stuff in this class)
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causes SIADH
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vincristine
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inhibits topoisomerase II
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etoposide
doxorubicin |
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bind tubulin
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taxanes
vincas |
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peripheral neuropathy
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taxol (not taxotere so much)
vincristine cisplatin |
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heart failure
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doxorubicin
high dose cyclophosphamide |
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lung damage
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bleo
BCLU |
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Kidney damage
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cisplatin
cyclophosphamide - acrolein (which mesna can prevent) |
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neuro
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vincristine
taxols cisplatin |
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anaphylaxis
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taxols
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nephron toxicity
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cisplatin
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neutropenia
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topotecan (topotenia)
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diarrhea
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irinotecan (rino runs-o!)
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action of vincristin
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spindle poison
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action of methotrexate
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DHFR inhibitor
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action of imatinib
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TK inhibitor (Bcr-abl)
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action of cyclophosphamide
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metabolized to acrolein
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action of ifosfamide
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metabolized to chloracetaldehyde
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activity of etoposide
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topoisomerase II inhibitor
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cuases pulmonary toxicity
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bleomycin
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causes hemorrhagic cystitis
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cyclophosphamide
ifosfamide |
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causes seizures
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ifosfamide
any BBB crossing meds (nitrosureas like carmustin, tiazenes like dacarbazine) |
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hypersensitivity reactions
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Asparaginase
taxols |
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ototoxicity
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cisplatin
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congestive cardiomyopathy
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doxorubicin
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severe diarrhea
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irinotecan
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peripheral neuropathy
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cisplatin
vincristine taxol |
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alopecia
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cytarabine
taxanes |
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enhanced by leucovorin
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5 fluoro
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blocks pyrimidines
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5 fluoro
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inhibits thymidilate synthetase
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5 fluoro
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inhibits nucleoside diphosphate reductase
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cytarabine
hydroxyurea |
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inhibits DNA polymerase
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cytarabine
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inhibits prpp amidotransferase
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thiopurine
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used for anemia
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EPO, CSF
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enhances PMN activity
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G-CSF, GM-CSF
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enhances PMN and eos activity
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GM-CSF
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associated with endometrial cancer
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tamoxifen
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decreases libido and causes impotence
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leuprolide (GnRH analog)
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covalently bind DNA
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carboplatin
cisplatin |
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prodrug
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cyclophosphamide
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causes capillary leak
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taxotere
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forms free radicals
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doxorubicin
idarubicin bleomycin |
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makes the microtubules nonfunctional
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taxanes
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constipates
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vincristine
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lowers liver protein production
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l'asparaginase
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topo I inhibitor
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the tecans
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intercalators
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doxorubicin
idarubicin |
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nitrogen mustards
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cyclophosphamide
ifosfamide |
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needs to be given IV becaues rapidly deactivated
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cytarabine
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