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18 Cards in this Set
- Front
- Back
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Types of Hematologic Malignancies
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Leukemias
Lymphomas Multiple myeloma Myeloproliferative disorders |
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-------------------is plasma cell disorder arising from antibody-secreting B lymphocytes
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Multiple myeloma
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Myeloid verus Lymphocytic leukemias
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Origin:
Myeloid - granulocytes, monocytes, erythrocytes, platelets where as lymphocytic refers to B and T cell origin |
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Type of Leukemias based on
natural course of disease |
Acute and Chronic
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Types of Acute Leukemias
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Acute myelogenous leukemia(AML)
Acute lymphocytic leukemia(ALL) |
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Types of Chronic
leukemias |
Chronic myelogenous leukemia(CML)
Chronic lymphocytic leukemia(CLL) |
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Acute Leukemias - Presentation
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-Bone marrow suppression
Neutropenia – infection, fever Thrombocytopenia – bleeding Anemia – fatigue -Skin and gum infiltration – monocytic -Leukostasis – increased blood viscosity and blast cell emboli in CNS and lungs -Bleeding due to coagulopathy – promyelocytic -Hyperuricemia -CNS infiltration – headache, cranial nerve palsy, coma, seizures |
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Supportive Care Treatment for Acute Leukemias
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Prevention of cell lysis syndrome
Infection prevention Platelet and RBC transfusions |
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Hypogammaglobulinemia is presented in which type of leukemia?
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Chronic Lymphocytic Leukemia(CLL)
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tests used to distinguish the various hematologic malignancies
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CBC with differential
Bone marrow biopsy (Morphology Cytogenetics Cytochemical stains Surface membrane immunophenotyping) |
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Risk factors for Multiple Myeloma
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chronic immune stimulation, exposure to pesticides, radiation, HIV infection
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Expresses high levels of a single immunoglobulin – IgG, IgA
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Multiple Myeloma
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Multiple Myeloma diagnosis
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Plasmacytosis (<10% in bone marrow) or plasmacytoma
Lytic bone lesions or other end organ damage Serum M protein or Bence Jones proteinuria |
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Aggressive type Non-Hodgkin Lymphomas versus Follicular type
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Follicular – tends to be indolent but persistent
Median survival: 8-12 years -Aggressive – many are curable; if resistant to therapy – rapid progression |
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Typically arises from a single lymph node and spreads to contiguous areas;Link to EBV
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Hodgkin Lymphomas
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4 variants of Hodgkin Lymphomas
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nodular sclerosing, lymphocyte rich,
lymphocyte depleted, mixed cellularity |
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is characterized by having Bimodal age distribution
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Hodgkin Lymphomas
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presents as painless enlargement of one or more lymph nodes
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Hodgkin Lymphomas
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