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7 Cards in this Set
- Front
- Back
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Evidence for need for multiple mutations in cancer
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young people have low instance of cancer, need time to accumulate mutations.
also factory workers exposed for longer periods of time have higher instances of cancer |
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What kinds of cells are tumors derived from?
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Tumors are derived from a single abnormal cell
they are heterogeneic however because of genetic instability will be very different from eachother with different mutations |
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Carcinogenesis
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initiated by a mutagenic event and propogated by the tumor
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Initiator event
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a mutational event that can cause cancer has to be caused by some sort of mutagen
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Promoter event
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an event that promotes cell division
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Chronic myeolid leukemia
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cross over event between 9 and 22
called a philadelphia chromosome Abl and Bcr is linked blc-abl is a sarc and constitutively active gleevec is a drug for it which prevents phosphorylation by competitively inhibiting ATP in teh active site and therefore blocks the leukemia |
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cancer stem cells
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telomere expression is high and results in immortality
ABC transporter high giving drug resistance proliferation rates are low giving resistance to drugs that select on cells dividing rapidly may arise from differentiated cells in tumor through mutational and epigenetic changes |
