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32 Cards in this Set
- Front
- Back
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abl gene
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CML
oncogene Tyrosine kinase |
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c-myc gene
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Burkitt's lymphoma
oncogene Transcription factor |
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bcl-2 gene
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follicular and undifferentiated lymphomas
oncogene anti-apoptotic molecule |
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erb-B2 gene
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breast, ovarian, and gastric carcinomas
oncogene Tyrosine kinase |
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K-ras
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colon carcinoma
oncogene GTPase |
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L-myc
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lung tumor
oncogene transcription factor |
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N-myc
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neuroblastoma
oncogene transcription factor |
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ret
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MEN IIA and IIB
oncogene Tyrosine kinase |
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c-kit
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gastrointestinal stromal tumor (GIST)
oncogene cytokine receptor |
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Rb
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retinoblastoma, osteosarcoma
Tumor suppressor gene product blocks G1-->S phase of cell cycle chromosome 13q |
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p53
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Most human cancers, Li-Fraumeni syndrome
tumor suppressor gene product blocks G1-->S phase of cell cycle chromosome 17p |
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BRCA1
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Breast and ovarian cancer
tumor suppressor gene DNA repair protein chromosome 17q |
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BRCA2
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breast cancer
tumor suppressor gene DNA repair protein 13q |
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p16
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Melanoma
tumor suppressor gene |
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APC
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colorectal cancer
tumor suppressor gene associated with FAP, Gardner's syndrome chromosome 5q |
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WT1
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Wilm's tumor
Tumor suppressor gene |
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NF1
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Neurofibromatosis 1
Tumor suppressor gene chromosome 17q |
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NF2
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Neurofibromatosis 2
Tumor suppressor gene chromosome 22q |
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DPC
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pancreatic cancer
tumor suppressor gene "Deleted in Pancreatic Cancer" |
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DCC
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colon cancer
tumor suppressor gene "Deleted in Colon Cancer" |
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PSA
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Prostate-specific antigen
screen for prostate carcinoma also elevated w/BPH and prostatitis |
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Prostatic acid phosphatase
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Prostate carcinoma
more specific than PSA |
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CEA
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carcinoembryonic antigen
non-specific produced by ~70% of colorectal and pancreatic cancers also gastric, breast, and thyroid medullary carcinomas |
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AFP
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alpha-fetoprotein
hepatocellular carcinomas nonseminomatous germ cell tumors of the testes (yolk sac/endodermal sinus tumors) |
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B-hCG
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hydatidiform moles
choriocarcinoma |
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CA-125
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ovarian, malignant epithelial tumors
can be elevated with any peritoneal irritation |
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S-100
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Melanoma
Neural tumors Astrocytomas |
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Alkaline phosphatase
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Bone mets
obstructive biliary disease Paget's disease of the bone |
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Bombesin
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neuroblastoma
lung cancer gastric cancer |
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TRAP
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tartrate resistant acid phosphatase
hairy cell leukemia (B cell neoplasm) "Hair TRAP in the LEUKwarm Bath" |
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CA-19-9
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pancreatic adenocarcinoma
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Calcitonin
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thyroid medullary carcinoma
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