• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

Card Range To Study

through

image

Play button

image

Play button

image

Progress

1/31

Click to flip

Use LEFT and RIGHT arrow keys to navigate between flashcards;

Use UP and DOWN arrow keys to flip the card;

H to show hint;

A reads text to speech;

31 Cards in this Set

  • Front
  • Back
MOA: Vincristine & Vinblastine
inhibits microtubule polymerization
Vincristine & Vinblastine make two populations of microtubules that can be described as:
1 growing & stable

2 shrinking & unstable
DOC to induce remission in lymphocytic leukemia
Vincristine
DL SE of Vincristine
Neurological tox (peripheral sensory)

*Fatal if given intrathecally

VinCristine = CNS tox
DL SE of Vinblastine
Myelosuppression (BMD)

VinBlastine = BMD
MOA of Paclitaxel & Docetaxel
binds to tubulin and hyperstabilizes microtubules (so mitotic spindles can't breakdown causing apoptosis)
DL SE of Paclitaxel
peripheral neuropathy & BMD
DL SE of Docetaxel
Fluid Retention & (same as Paclitaxel)...

Neurotoxicity & BMD
Etoposide MOA
inhibits topoisomerase II

(causes DNA strand breaks leading to apoptosis)
Etoposide SE
BMD
Topotecan & Irinotecan drug class & MOA
Class: Camptothecin analogs

topoisomerase I inhibitors
DL SE of Topotecan & Irinotecan
Both: BMD

dIarrhea only in...........Irinotecan
What are the 4 antibiotic cancer drugs?
Dactomycin, Doxorubicin, Daunorubicin, Bleomycin
MOA Dactomycin
intercalation of DNA, which blocks DNA & RNA syn.
DL SE of Dactomycin
BMD

(stomatitis & proctitis)
MOA of Doxorubicin & Daunorubicin (3 things)
1 intercalates in DNA

2 inhibits topoisomerase II

3 free radical formation
Doxorubicin & Daunorubicin resistance
as with all natural agents the chief resistance agent is...P-glycoprotein
Doxorubicin & Daunorubicin DL SE
BMD in both

Cardiotox from Dox only *due to free radicals*
MOA of Bleomycin

**unique!**
*metal ion chelator* that causes DNA strand breaks (forms free radicals)

**DNA-Bleomycin-Fe(II) complex causes oxidation damage causing DNA fragmentation**
Bleomycin DL SE
Pulmonary tox*/pulmonary fibrosis**
Cutaneous tox*
minimal myelosuppression* (significant advantage)
L-Asparaginase MOA
hydrolyzes circulating L-asparagine which some tumors can't make and hence therefore cell death
L-Asparaginase DL SE
Anaphylaxis**

Coagulopathy, thrombosis, CNS, Pancreatitis, Glucose intolerance
Prednisone

drug class & MOA & SE
Glucocorticoid

suppresses lymphocyte proliferation

Cushings, CNS, osteoporosis, myopathy, etc.
Tamoxifen

Class & MOA
Anti-estrogen

binds to estrogen receptor (good for ER+ breast cancer treatment and prevention)
Tamoxifen Tox
WELL TOLERATED

after years of treatment increased risk of uterine malignancy, stroke, & pulmonary embolism
Anastrozole

Class & MOA
Aromatase Inhibitor

inhibits adrenal steroid syn & aromatase conversion of androgens to estogren

good for ER+ cancers and progesterone receptor (PR+) cancers
Bortezomib

Class & MOA
Targeted for Multiple Myeloma

inhibits 26S proteasome to disrupt cell signaling
Imatinib

Class & MOA & use
Targeted agent

inhibits Bcr-Abl tyrosine kinase
**signal transduction inhibitor**

chronic myelogenous leukemia
Trastuzumab

Class & MOA
Monoclonal Antibody

blocks HER-2 receptor

good of ER- breast cancer (Women TRAST HER-2 breast)
Bevacizumab

Class & MOA
Monoclonal Antibody

blocks VEGF (vascular endothelial growth factor)
Hydroxyurea

MOA & DL SE
inhibits ribonucleotide reductase (& hence DNA syn)

Myelosuppression