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31 Cards in this Set
- Front
- Back
MOA: Vincristine & Vinblastine
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inhibits microtubule polymerization
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Vincristine & Vinblastine make two populations of microtubules that can be described as:
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1 growing & stable
2 shrinking & unstable |
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DOC to induce remission in lymphocytic leukemia
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Vincristine
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DL SE of Vincristine
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Neurological tox (peripheral sensory)
*Fatal if given intrathecally VinCristine = CNS tox |
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DL SE of Vinblastine
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Myelosuppression (BMD)
VinBlastine = BMD |
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MOA of Paclitaxel & Docetaxel
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binds to tubulin and hyperstabilizes microtubules (so mitotic spindles can't breakdown causing apoptosis)
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DL SE of Paclitaxel
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peripheral neuropathy & BMD
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DL SE of Docetaxel
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Fluid Retention & (same as Paclitaxel)...
Neurotoxicity & BMD |
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Etoposide MOA
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inhibits topoisomerase II
(causes DNA strand breaks leading to apoptosis) |
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Etoposide SE
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BMD
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Topotecan & Irinotecan drug class & MOA
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Class: Camptothecin analogs
topoisomerase I inhibitors |
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DL SE of Topotecan & Irinotecan
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Both: BMD
dIarrhea only in...........Irinotecan |
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What are the 4 antibiotic cancer drugs?
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Dactomycin, Doxorubicin, Daunorubicin, Bleomycin
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MOA Dactomycin
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intercalation of DNA, which blocks DNA & RNA syn.
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DL SE of Dactomycin
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BMD
(stomatitis & proctitis) |
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MOA of Doxorubicin & Daunorubicin (3 things)
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1 intercalates in DNA
2 inhibits topoisomerase II 3 free radical formation |
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Doxorubicin & Daunorubicin resistance
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as with all natural agents the chief resistance agent is...P-glycoprotein
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Doxorubicin & Daunorubicin DL SE
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BMD in both
Cardiotox from Dox only *due to free radicals* |
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MOA of Bleomycin
**unique!** |
*metal ion chelator* that causes DNA strand breaks (forms free radicals)
**DNA-Bleomycin-Fe(II) complex causes oxidation damage causing DNA fragmentation** |
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Bleomycin DL SE
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Pulmonary tox*/pulmonary fibrosis**
Cutaneous tox* minimal myelosuppression* (significant advantage) |
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L-Asparaginase MOA
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hydrolyzes circulating L-asparagine which some tumors can't make and hence therefore cell death
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L-Asparaginase DL SE
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Anaphylaxis**
Coagulopathy, thrombosis, CNS, Pancreatitis, Glucose intolerance |
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Prednisone
drug class & MOA & SE |
Glucocorticoid
suppresses lymphocyte proliferation Cushings, CNS, osteoporosis, myopathy, etc. |
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Tamoxifen
Class & MOA |
Anti-estrogen
binds to estrogen receptor (good for ER+ breast cancer treatment and prevention) |
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Tamoxifen Tox
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WELL TOLERATED
after years of treatment increased risk of uterine malignancy, stroke, & pulmonary embolism |
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Anastrozole
Class & MOA |
Aromatase Inhibitor
inhibits adrenal steroid syn & aromatase conversion of androgens to estogren good for ER+ cancers and progesterone receptor (PR+) cancers |
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Bortezomib
Class & MOA |
Targeted for Multiple Myeloma
inhibits 26S proteasome to disrupt cell signaling |
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Imatinib
Class & MOA & use |
Targeted agent
inhibits Bcr-Abl tyrosine kinase **signal transduction inhibitor** chronic myelogenous leukemia |
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Trastuzumab
Class & MOA |
Monoclonal Antibody
blocks HER-2 receptor good of ER- breast cancer (Women TRAST HER-2 breast) |
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Bevacizumab
Class & MOA |
Monoclonal Antibody
blocks VEGF (vascular endothelial growth factor) |
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Hydroxyurea
MOA & DL SE |
inhibits ribonucleotide reductase (& hence DNA syn)
Myelosuppression |