Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
9 Cards in this Set
- Front
- Back
|
Alkylators
|
Mechanism of Action: Damage DNA by adding a carbon adduct covalently to specific bases
Metabolism: ???? Toxicity: Myelosuppression, N/V, hair loss, ov/test failure, leukemia Common examples: Nitrogen Mustard, Cyclophosphamide |
|
|
Platinum Compounds
|
MOA: Damage DNA by adding platinum to the same DNA strand
Metabolism: Cleared by renal system, thus require renal function Toxicity: Kidney damage, bone marrow suppression Common examples: Cisplatin, Carboplatin, Oxaliplatin |
|
|
Antimetabolites
|
MOA: Interfere with DNA synthesis by deleting pools of nucleotides
Metabolism: Toxicity: Diarrhea, mouth sores, bone marrow suppression Common Examples: Methotrexate, Fluorouracil (Capecitabine), Gemcitabine |
|
|
Topoisomerase Inhibitors
|
MOA: Damage DNA by interfering with action of an enzyme needed for unwinding DNA for replication and transcription
Metabolism: Toxicity: Anthracyclines (doxorubicin) - heart damage Common Examples: Doxorubicin (Top II), Irinotecan (Top I), Etoposide |
|
|
Microtubule Binding Agents
|
MOA: Disrupt mitosis by damaging the structure needed for the physical separation of chromosomes into daughter cells
Metabolism: Toxicity: Peripheral neuropathy Common examples: Vincristine (Vincas - prevent assembly), Vinorelbine, Paclitaxel, Docetaxel, Taxanes (prevent disassembly) |
|
|
Hormonal Therapies
|
MOA: Interfere with hormones that stimulate cancer growth
Metabolism: Toxicity: Common examples: Tamoxifen (ER blocker), Aromatase Inhibitors (Anastrazole), LHRH Agonist |
|
|
Antibodies
|
MOA: Bind specifically to protein targets on the surface of cancer cells
Metabolism: Toxicity: Cardiac toxicity - trastuzumab; Leucopenia - Rituximab Common examples: Trastuzumab, Rituximab, Cetuximab |
|
|
Tyrosine Kinase Inhibitors
|
MOA: Interfere with specific growth factor receptors or intracellular messengers that have a tyrosine kinase function
Metabolism: Toxicity: Common examples: Sunitinib, Erlotinib, Lapatinib, Imatinib (Silver bullet for leukemia) |
|
|
Immune Modulators
|
MOA: Inhibit new blood vessel formation by uncertain mechanisms
Metabolism: Toxicity: Common examples: Thalidomide, Lenalidomide |
