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16 Cards in this Set
- Front
- Back
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What is a nitrogen mustard drug?
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cyclophosphamide
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What is a nitrosurea drug?
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lomutsine
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What are the anthacycline antibiotics?
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daunorubicin and doxorubicin
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What are the side effects of daunorubicin and doxorubicin?
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acute cardiac changes, chronic CUMULATIVE CARDIOTOXICITY
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How to daunorubicin and doxorubicin work?
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drug binds to DNA and topoisomerase II
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what is the mechanism of action of dactinomycin
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DNA cross linking, DNA intercalation
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What are the side effects of dactinomycin
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skin eruptions, hyperkeratosis
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What is the mechanism of action of bleomycin
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effects on DNA molecules, binding, intercalation, strand breaks
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What are the side effects of bleomycin
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fever, blistering, stomatitis, pulmonary fibrosis
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What is the action of dexamethasone
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cytolysis
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what is the action of tamoxifen?
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anti-estrogen, action requires presence of estrogen receptors
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What are the side effects of tamoxifen?
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mild hot flashes, chronic use may cause uterine effects, endometriosis, uterine cancer, blood-clotting abnormalities
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Action of flutamimde?
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anti-androgen
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What are the side effects of flutamide?
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suppression of androgens and its consequences
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What is a platinum compound?
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cisplatin
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What is used as supportive therapy
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allopurinol
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