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133 Cards in this Set
- Front
- Back
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What neoplasms are a/w:
Down's syndrome |
ALL & AML
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What neoplasms are a/w:
Xeroderma pigmentosum |
Melanoma, Basal cell carcinoma & Squamous cell carcinoma
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What neoplasms are a/w:
Chronic gastritis, Pernicious anemia & postsurgical gastric remnants |
Gastric adenocarcinoma
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What neoplasms are a/w:
Tuberous Sclerosis |
Astrocytoma & cardiac rhabdomyoma
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What neoplasms are a/w:
Actinic keratosis |
Squamous cell carcinoma of the skin
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What neoplasms are a/w:
Barrett's esophagus |
Esophageal adenocarcinoma
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What neoplasms are a/w:
Plummer-Vinson syndrome |
Squamous cell carcinoma of esophagous
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What neoplasms are a/w:
Liver cirrhosis |
Hepatocellular carcinoma
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What neoplasms are a/w:
Ulcerative colitis |
Colonic adenocarcinoma
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What neoplasms are a/w:
Paget's disease of bone |
Secondary osteosarcoma & fibrosarcoma
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What neoplasms are a/w:
Immunodeficiency states |
Malignant lymphomas
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What neoplasms are a/w:
AIDS |
Aggresive malignant lymphomas(non-hodgkins) & Kaposi's sarcoma
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What neoplasms are a/w:
Autoimmune disease |
Benign & malignant thymomas
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What neoplasms are a/w:
Acanthosis nigricans |
Visceral malignancy (stomach, breast, lungs)
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What neoplasms are a/w:
Dysplastic nevus |
Malignant melanoma
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What is the following gene:
abl |
Oncogene
a/w CML |
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What is the following gene:
c-myc |
Oncogene
a/w Burkitt's lymphoma |
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What is the following gene:
bcl-2 |
Oncogene
a/w Follicular & undifferentiated lymphomas |
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What is the following gene:
erb-B2 |
Oncogene
a/w Breast, ovarian & gastric carcinoma |
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What is the following gene:
ras |
Oncogene
a/w Colon carcinoma |
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What is the following gene:
L-myc |
Oncogene
a/w Lung tumor |
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What is the following gene:
N-myc |
Oncogene
a/w Neuroblastoma |
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What is the following gene:
ret |
Oncogene
a/w MEN types II & III |
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What is the following gene:
Rb |
Tumor suppressor gene
a/w Retinoblastoma & Osteosarcoma chrom 13q |
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What is the following gene:
BRCA 1 & 2 |
Tumor suppressor gene
a/w Breast & Ovarian cancer chrom 17q & 13q |
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What is the following gene:
p53 |
Tumor suppressor gene
a/w Most human cancers, Li-Fraumeni syndrome chrom 17p |
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What is the following gene:
p16 |
Tumor suppressor gene
a/w Melanoma chrom 9p |
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What is the following gene:
APC |
Tumor suppressor gene
a/w Colorectal cancer chrom 5q |
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What is the following gene:
WT1 |
Tumor suppressor gene
a/w Wilm's tumor chrom 11q |
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What is the following gene:
NF1 |
Tumor suppressor gene
a/w Neurofibromatosis type I chrom 17q |
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What is the following gene:
NF2 |
Tumor suppressor gene
a/w Neurofibromatosis type 2 chrom 22q |
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What is the following gene:
DPC |
Tumor suppressor gene
a/w Pancreatic cancer chrom 18q |
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What is the following gene:
DCC |
Tumor suppressor gene
a/w Colon cancer chrom 18q |
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Tumor marker for what?
PSA |
Prostatic carcinoma
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Tumor marker for what?
CEA |
Nonspecific
Produced by 70% of colorectal & pancreatic cancers Also produced by gastric & breast carcinomas |
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Tumor marker for what?
alpha-fetoprotein |
Hepatocellular carcinoma & nonseminomatous germ cell tumors of the testes(e.g yolk sac tumor)
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Tumor marker for what?
beta-hCG |
Hydatidiform moles, Choriocarcinomas & Gestational trophoblastic tumors
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Tumor marker for what?
CA-125 |
Ovarian tumors & Malignant epithelial tumors
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Tumor marker for what?
S-100 |
Melanoma, neural tumors & astrocytoma
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Tumor marker for what?
Alkaline phosphatase |
Metastases to bone(blastic), Obstruuctive biliary disease & Paget's disease of bone
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Tumor marker for what?
Bombesin |
Neuroblastoma, Lung cancer, Gastric cancer
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Tumor marker for what?
TRAP |
Hairy cell leukemia(B-cell neoplasm)
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Tumor marker for what?
CA-19-9 |
Pancreatic adenocarcinoma
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What cancer can be caused by:
HTLV-1 |
Adult T-cell leukemia
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What cancer can be caused by:
HBV & HCV |
Hepatocellular carcinoma
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What cancer can be caused by:
EBV |
Burkitt's lymphoma & nasopharyngeal carcinoma
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What cancer can be caused by:
HPV |
Cervical carcinoma & Penile/anal carcinomas
from types 16 & 18 |
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What cancer can be caused by:
HHV-8 |
Kaposi's sarcoma & Body cavity fluid B-cell lymphoma
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Carcinogenic affect of:
Aflatoxin |
Hepatocellular carcinoma
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Carcinogenic affect of:
Vinyl chloride |
Angiosarcoma of liver
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Carcinogenic affect of:
CCl4 |
Centrilobular necrosis & fatty change in liver
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Carcinogenic affect of:
Nitrosamines |
Affects esophagus & stomach
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Carcinogenic affect of:
Cigarete smoke |
Affects larynx & lungs
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Carcinogenic affect of:
Asbestos |
Mesothelioma & bronchogenic carcinoma of the lung
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Carcinogenic affect of:
Arsenic |
Squamous cell carcinoma of the skin
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Carcinogenic affect of:
Naphthalene(aniline) dyes |
Transitional cell carcinoma of the bladder
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Carcinogenic affect of:
Alkylating agents |
Leukemia
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Most common cancer to metastasize to liver?
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Colon cancer
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2nd most common cancer to metastasize to liver?
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Stomach
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Most common metastases to bone?
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Breast & Prostate cancers
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Lytic or blastic?
Lung metastases to bone |
Lytic
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Lytic or blastic?
Prostate metastases to bone |
Blastic
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Lytic or blastic?
Breast metastases to bone |
Both lytic & blastic
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Most common cancer in males?
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Prostate (32%)
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2nd most common cancer in males?
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Lung (16%)
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3rd most common cancer in males?
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Colorectal (12%)
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Most common cancer in females?
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Breast (32%)
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2nd most common cancer in females?
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Lung (13%)
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3rd most common cancer in females?
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Colorectal (13%)
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Most common cancer death in males?
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Lung (33%)
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2nd most common cancer death in males?
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Prostate (13%)
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Most common cancer death in females?
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Lung (23%)
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2nd most common cancer death in females?
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Breast (18%)
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"Starry-sky" appearance
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Burkitt's Lymphoma
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t(14;18)
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Follicular Lymphoma
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t(9;22)
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CML
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c-myc gene translocation
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Burkitt's Lymphoma
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bcl-2 activation
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Follicular Lymphoma
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Bence Jones protein
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Multiple Myeloma
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Leukemia that may spread to CNS and testes
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ALL
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a/w EBV
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Hodgkin's Lymphoma & Burkitt's Lymphoma
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Leukemia in children
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ALL
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Hodgkin's Lymphoma- More common in men or women overall?
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Men
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Erythroblastic AML
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M6
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bcr-abl hybrid
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CML
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Type of Hodgkin's Lymphoma w/ the worst prognosis
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Lymphocyte depleted type of Hodgkin's Lymphoma
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Monoclonal Immunoglobulin spike of IgG or IgA
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M protein- a/w Multiple Myeloma
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Reed-Sternberg Cells
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Hodgkin's Lymphoma
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Leukemia that is most responsive to therapy
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ALL
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Promyelocytic AML
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M3
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Monoblastic AML
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M5
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t(11;22)
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Ewing's Sarcoma
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t(8;14)
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Burkitt's Lymphoma
c-myc & Ig heavy chain |
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Megakaryoblastic AML
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M7
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"Fried Egg" Plasma Cells
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Multiple Myeloma
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Leukemia in older adults
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CLL
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Type of Hodgkin's Lymphoma w/ highest level of Reed-Sternberg cells
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Mixed Cellularity type of Hodgkin's Lymphoma
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Type of Hodgkin's Lymphoma that is more common in women
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Nodular Sclerosing type of Hodgkin's Lymphoma
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Lymphoma a/w jaw lesions in the endemic form in Africa
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Burkitt's Lymphoma
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aggresive T-cell lymphoma in children
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Lymphoblastic Lymphoma
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CD30+ and CD15+ B-cells
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Hodgkin's Lymphoma
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3rd most common type of Hodgkin's Lymphoma
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Lymphocyte Predominant type of Hodgkin's Lymphoma
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CD5+ B Cells
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Mantle Cell Lymphoma
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Most common type of Hodgkin's Lymphoma
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Nodular Sclerosing type of Hodgkin's Lymphoma
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Undifferentiated AML
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M0
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Philadelphia Chromosome
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CML
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t(15;17)
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M3 type of AML
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t(11:14)
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Mantle cell Lymphoma
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Monoclonal Immunoglobulin spike of IgM
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Waldenstrom's macroglobulinemia
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Myeloblastic AML
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M1
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High RBC count w/ low or normal serum EPO
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Polycythemia Vera
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Myeloproliferative Disorder a/w pruritis
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Polycythemia Vera
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Myelomonoblastic AML
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M4
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Myeloblastic with differentiation AML
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M2
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2nd most common type of Hodgkin's Lymphoma
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Mixed Cellularity type of Hodgkin's Lymphoma
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Neutrophilic Leukocytosis w/ a left shift
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CML
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Punched-out lytic bone lesions
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Multiple Myeloma
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Least common type of Hodgkin's Lymphoma
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Lymphocyte Depleted type of Hodgkin's Lymphoma
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Most common Lymphoma in children
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Burkitt's Lymphoma
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Lymphoma that resembles CLL
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Small lymphocytic Lymphoma
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Increased Leukocyte Alkaline Phosphate
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Leukemoid Reaction
Resembles CML but can be differentiated based on high LAP |
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Rouleau formation
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RBC's stacked like poker chips on Blood smear
a/w Multiple Myeloma |
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Ig light chains in urine
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Bence Jones protein
a/w Multiple Myeloma |
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"Blast Crisis"
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CML
Occurs when the CML accelerates to AML |
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Lacunar Cells
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type of Reed-Sternberg Cell
a/w Nodular Sclerosing type of Hodgkin's Lymphoma |
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Decreased Leukocyte Alkaline Phosphate
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CML
Very low LAP helps differentiate CML from leukemoid reaction (which has a high LAP) |
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Bilobed Tumor Giant Cell that looks like "owl's eyes"
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Reed-Sternberg Cells
a/w Hodgkin's Lymphoma |
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Auer Rods
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AML (Primarily seen in M3)
Auer Rods- Peroxidase(+) cytoplasmic inclusions in granulocytes and myeloblasts |
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Leukemia w/ peak incidence from 35-50 years old
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CML
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Leukemia that most commonly occurs in people older than 60
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CLL
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Leukemia that most commonly affects children
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ALL
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t(8;22)
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Burkitt's Lymphoma
c-myc & lambda light chain This translocation is not as common as t(8;14) |
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t(2;8)
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Burkitt's Lymphoma
c-myc & kappa light chain This translocation is not as common as t(8;14) |
