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133 Cards in this Set

  • Front
  • Back
What neoplasms are a/w:
Down's syndrome
ALL & AML
What neoplasms are a/w:
Xeroderma pigmentosum
Melanoma, Basal cell carcinoma & Squamous cell carcinoma
What neoplasms are a/w:
Chronic gastritis, Pernicious anemia & postsurgical gastric remnants
Gastric adenocarcinoma
What neoplasms are a/w:
Tuberous Sclerosis
Astrocytoma & cardiac rhabdomyoma
What neoplasms are a/w:
Actinic keratosis
Squamous cell carcinoma of the skin
What neoplasms are a/w:
Barrett's esophagus
Esophageal adenocarcinoma
What neoplasms are a/w:
Plummer-Vinson syndrome
Squamous cell carcinoma of esophagous
What neoplasms are a/w:
Liver cirrhosis
Hepatocellular carcinoma
What neoplasms are a/w:
Ulcerative colitis
Colonic adenocarcinoma
What neoplasms are a/w:
Paget's disease of bone
Secondary osteosarcoma & fibrosarcoma
What neoplasms are a/w:
Immunodeficiency states
Malignant lymphomas
What neoplasms are a/w:
AIDS
Aggresive malignant lymphomas(non-hodgkins) & Kaposi's sarcoma
What neoplasms are a/w:
Autoimmune disease
Benign & malignant thymomas
What neoplasms are a/w:
Acanthosis nigricans
Visceral malignancy (stomach, breast, lungs)
What neoplasms are a/w:
Dysplastic nevus
Malignant melanoma
What is the following gene:
abl
Oncogene
a/w CML
What is the following gene:
c-myc
Oncogene
a/w Burkitt's lymphoma
What is the following gene:
bcl-2
Oncogene
a/w Follicular & undifferentiated lymphomas
What is the following gene:
erb-B2
Oncogene
a/w Breast, ovarian & gastric carcinoma
What is the following gene:
ras
Oncogene
a/w Colon carcinoma
What is the following gene:
L-myc
Oncogene
a/w Lung tumor
What is the following gene:
N-myc
Oncogene
a/w Neuroblastoma
What is the following gene:
ret
Oncogene
a/w MEN types II & III
What is the following gene:
Rb
Tumor suppressor gene
a/w Retinoblastoma & Osteosarcoma
chrom 13q
What is the following gene:
BRCA 1 & 2
Tumor suppressor gene
a/w Breast & Ovarian cancer
chrom 17q & 13q
What is the following gene:
p53
Tumor suppressor gene
a/w Most human cancers, Li-Fraumeni syndrome
chrom 17p
What is the following gene:
p16
Tumor suppressor gene
a/w Melanoma
chrom 9p
What is the following gene:
APC
Tumor suppressor gene
a/w Colorectal cancer
chrom 5q
What is the following gene:
WT1
Tumor suppressor gene
a/w Wilm's tumor
chrom 11q
What is the following gene:
NF1
Tumor suppressor gene
a/w Neurofibromatosis type I
chrom 17q
What is the following gene:
NF2
Tumor suppressor gene
a/w Neurofibromatosis type 2
chrom 22q
What is the following gene:
DPC
Tumor suppressor gene
a/w Pancreatic cancer
chrom 18q
What is the following gene:
DCC
Tumor suppressor gene
a/w Colon cancer
chrom 18q
Tumor marker for what?
PSA
Prostatic carcinoma
Tumor marker for what?
CEA
Nonspecific
Produced by 70% of colorectal & pancreatic cancers
Also produced by gastric & breast carcinomas
Tumor marker for what?
alpha-fetoprotein
Hepatocellular carcinoma & nonseminomatous germ cell tumors of the testes(e.g yolk sac tumor)
Tumor marker for what?
beta-hCG
Hydatidiform moles, Choriocarcinomas & Gestational trophoblastic tumors
Tumor marker for what?
CA-125
Ovarian tumors & Malignant epithelial tumors
Tumor marker for what?
S-100
Melanoma, neural tumors & astrocytoma
Tumor marker for what?
Alkaline phosphatase
Metastases to bone(blastic), Obstruuctive biliary disease & Paget's disease of bone
Tumor marker for what?
Bombesin
Neuroblastoma, Lung cancer, Gastric cancer
Tumor marker for what?
TRAP
Hairy cell leukemia(B-cell neoplasm)
Tumor marker for what?
CA-19-9
Pancreatic adenocarcinoma
What cancer can be caused by:
HTLV-1
Adult T-cell leukemia
What cancer can be caused by:
HBV & HCV
Hepatocellular carcinoma
What cancer can be caused by:
EBV
Burkitt's lymphoma & nasopharyngeal carcinoma
What cancer can be caused by:
HPV
Cervical carcinoma & Penile/anal carcinomas
from types 16 & 18
What cancer can be caused by:
HHV-8
Kaposi's sarcoma & Body cavity fluid B-cell lymphoma
Carcinogenic affect of:
Aflatoxin
Hepatocellular carcinoma
Carcinogenic affect of:
Vinyl chloride
Angiosarcoma of liver
Carcinogenic affect of:
CCl4
Centrilobular necrosis & fatty change in liver
Carcinogenic affect of:
Nitrosamines
Affects esophagus & stomach
Carcinogenic affect of:
Cigarete smoke
Affects larynx & lungs
Carcinogenic affect of:
Asbestos
Mesothelioma & bronchogenic carcinoma of the lung
Carcinogenic affect of:
Arsenic
Squamous cell carcinoma of the skin
Carcinogenic affect of:
Naphthalene(aniline) dyes
Transitional cell carcinoma of the bladder
Carcinogenic affect of:
Alkylating agents
Leukemia
Most common cancer to metastasize to liver?
Colon cancer
2nd most common cancer to metastasize to liver?
Stomach
Most common metastases to bone?
Breast & Prostate cancers
Lytic or blastic?
Lung metastases to bone
Lytic
Lytic or blastic?
Prostate metastases to bone
Blastic
Lytic or blastic?
Breast metastases to bone
Both lytic & blastic
Most common cancer in males?
Prostate (32%)
2nd most common cancer in males?
Lung (16%)
3rd most common cancer in males?
Colorectal (12%)
Most common cancer in females?
Breast (32%)
2nd most common cancer in females?
Lung (13%)
3rd most common cancer in females?
Colorectal (13%)
Most common cancer death in males?
Lung (33%)
2nd most common cancer death in males?
Prostate (13%)
Most common cancer death in females?
Lung (23%)
2nd most common cancer death in females?
Breast (18%)
"Starry-sky" appearance
Burkitt's Lymphoma
t(14;18)
Follicular Lymphoma
t(9;22)
CML
c-myc gene translocation
Burkitt's Lymphoma
bcl-2 activation
Follicular Lymphoma
Bence Jones protein
Multiple Myeloma
Leukemia that may spread to CNS and testes
ALL
a/w EBV
Hodgkin's Lymphoma & Burkitt's Lymphoma
Leukemia in children
ALL
Hodgkin's Lymphoma- More common in men or women overall?
Men
Erythroblastic AML
M6
bcr-abl hybrid
CML
Type of Hodgkin's Lymphoma w/ the worst prognosis
Lymphocyte depleted type of Hodgkin's Lymphoma
Monoclonal Immunoglobulin spike of IgG or IgA
M protein- a/w Multiple Myeloma
Reed-Sternberg Cells
Hodgkin's Lymphoma
Leukemia that is most responsive to therapy
ALL
Promyelocytic AML
M3
Monoblastic AML
M5
t(11;22)
Ewing's Sarcoma
t(8;14)
Burkitt's Lymphoma
c-myc & Ig heavy chain
Megakaryoblastic AML
M7
"Fried Egg" Plasma Cells
Multiple Myeloma
Leukemia in older adults
CLL
Type of Hodgkin's Lymphoma w/ highest level of Reed-Sternberg cells
Mixed Cellularity type of Hodgkin's Lymphoma
Type of Hodgkin's Lymphoma that is more common in women
Nodular Sclerosing type of Hodgkin's Lymphoma
Lymphoma a/w jaw lesions in the endemic form in Africa
Burkitt's Lymphoma
aggresive T-cell lymphoma in children
Lymphoblastic Lymphoma
CD30+ and CD15+ B-cells
Hodgkin's Lymphoma
3rd most common type of Hodgkin's Lymphoma
Lymphocyte Predominant type of Hodgkin's Lymphoma
CD5+ B Cells
Mantle Cell Lymphoma
Most common type of Hodgkin's Lymphoma
Nodular Sclerosing type of Hodgkin's Lymphoma
Undifferentiated AML
M0
Philadelphia Chromosome
CML
t(15;17)
M3 type of AML
t(11:14)
Mantle cell Lymphoma
Monoclonal Immunoglobulin spike of IgM
Waldenstrom's macroglobulinemia
Myeloblastic AML
M1
High RBC count w/ low or normal serum EPO
Polycythemia Vera
Myeloproliferative Disorder a/w pruritis
Polycythemia Vera
Myelomonoblastic AML
M4
Myeloblastic with differentiation AML
M2
2nd most common type of Hodgkin's Lymphoma
Mixed Cellularity type of Hodgkin's Lymphoma
Neutrophilic Leukocytosis w/ a left shift
CML
Punched-out lytic bone lesions
Multiple Myeloma
Least common type of Hodgkin's Lymphoma
Lymphocyte Depleted type of Hodgkin's Lymphoma
Most common Lymphoma in children
Burkitt's Lymphoma
Lymphoma that resembles CLL
Small lymphocytic Lymphoma
Increased Leukocyte Alkaline Phosphate
Leukemoid Reaction
Resembles CML but can be differentiated based on high LAP
Rouleau formation
RBC's stacked like poker chips on Blood smear
a/w Multiple Myeloma
Ig light chains in urine
Bence Jones protein
a/w Multiple Myeloma
"Blast Crisis"
CML
Occurs when the CML accelerates to AML
Lacunar Cells
type of Reed-Sternberg Cell
a/w Nodular Sclerosing type of Hodgkin's Lymphoma
Decreased Leukocyte Alkaline Phosphate
CML
Very low LAP helps differentiate CML from leukemoid reaction (which has a high LAP)
Bilobed Tumor Giant Cell that looks like "owl's eyes"
Reed-Sternberg Cells
a/w Hodgkin's Lymphoma
Auer Rods
AML (Primarily seen in M3)
Auer Rods- Peroxidase(+) cytoplasmic inclusions in granulocytes and myeloblasts
Leukemia w/ peak incidence from 35-50 years old
CML
Leukemia that most commonly occurs in people older than 60
CLL
Leukemia that most commonly affects children
ALL
t(8;22)
Burkitt's Lymphoma
c-myc & lambda light chain
This translocation is not as common as t(8;14)
t(2;8)
Burkitt's Lymphoma
c-myc & kappa light chain
This translocation is not as common as t(8;14)