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3 Cards in this Set
- Front
- Back
MOA
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The variety of calcium channels creates opportunities for drug selectivity
– The CVS calcium channel blockers are L-type selective – The calcium channel blockers have the broadest actions of all the CVS drugs Block the influx of calcium into cardiac and vascular smooth muscle cells – Decreased myocardial contractility=-ve inotrope |
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5 other points
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Vasodilation
especially coronary and peripheral arterial beds applications for ischemic heart disease (painful) improves peripheral blood flow decreases afterload >> heart (left ventricle) may contract more easily Slows atrioventricular (AV) impulse conduction • -ve chronotrope used as an antiarrhythmic for dysrhythmias |
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Amlodipine
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Feline hypertension
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