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3 Cards in this Set

  • Front
  • Back
MOA
The variety of calcium channels creates opportunities for drug selectivity
– The CVS calcium channel blockers are L-type selective
– The calcium channel blockers have the broadest actions of all the CVS drugs
Block the influx of calcium into cardiac and vascular smooth muscle cells
– Decreased myocardial contractility=-ve inotrope
5 other points
Vasodilation
especially coronary and peripheral arterial beds
 applications for ischemic heart disease (painful)
 improves peripheral blood flow
 decreases afterload >> heart (left ventricle) may contract more easily
Slows atrioventricular (AV) impulse conduction
• -ve chronotrope
 used as an antiarrhythmic for dysrhythmias
Amlodipine
Feline hypertension