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26 Cards in this Set

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describe hormone levels in 17 alpha hydroxylase defic
can't make it over to cortisol and testosterone paths (2,3 columns on R)
hi aldosterone, low testosterone, low cortisol
clinical 17 alpha hydroxy
HTN, low K, low glu, metabolic alkalosis. pheno female w/o maturation (ie pubic, axillary hair), and males are feminized
describe hormone levels in 21 beta hydroxylase defic
can't make it down final product in the aldosterone and cortisol columns (1,2), low aldosterone, low cortisol, hi testosterone,
clinical 21 beta hydroxy
masculinization, female pseudohermaphroditism, HYPOtension, low Na hi K hi renin, volume depletion. Salt wasting can lead to shock in neonate.
describe hormone levels in 11beta hydroxy
like 21 also can't make it down in production of cortisol, aldosterone (but blocked at difft enz farther down), low cortisol, low aldosterone, hi testosterone
clinical 11 beta hydroxy
masculinization and HTN (even though low cortisol, 11deoxycorticosterone acts as weak mineralcorticoid)
excess of what indicates 21 alpha
17-OH progesterone and progesterones
ACTH level in 21 hydroxy
for all these very high (bc no negative feedback), this leads to adrenal hyperplasia and even more androgen production
key ways to difft CAH
21-MC, only one with HYPOtension, and hi K
17-low K (HTN)
11-(HTN)
describe similarities and diff hormone and clinical presentations of CAH
both 11 and 21 have low cortisol, low aldosterone, hi testosterone, but 11 appears like 17 with HTN. 17 is almost opposite in terms of hormones hi aldosterone, low testosterone (low cortisol).
But again, 11 and 17 appear clinically similar eventhough 11, 21 have same hormone problems
what is glu level in hyperthyroid? how is that?
hi, by incr glycogenolysis and gluconeo (NOT glycolysis)
name steroid/thyroid hormones
PET CAT
Progesterone
Estrogen
Testosterone
Cortisol
Aldosterone
Thyroxine
(NOT PTH)
what steroids do in cell
bind inside cell to steroid binding protein which transforms R so now can bind to enhancer element protein inside the nucleus that enhancers transcription
inducers of P450
Queen Barb refuses common grocery pretzels
Quinidine
Barbituates
Rifampin
Phenytoin
Griseofulvin
Carbamazepine
(EtOH)
inhibit P450
ISCKEG
Isoniazid
Sulfanamide
Cimetidine
Ketoconazole
Erythromycin
Grapefruit jc
Rx can cause hemo in G6PD defic
sulfonamides, INH, primaquine, nitrofurantoin, pyrimethamine, chloramphenicol, ASA, ibuprofen
cause agranulocytosis
clozapine, carbamazepine, colchicine
disulfiram rxn
Met, some ceph, procarbazine, sulfonylureas
gynecomasti
Spirono, Digitalis cimetidine, alcohol, Ketoconazole
(some drug Create awesome knockers)
can cause SJ syndrome
ethosuximide, sulfonamides, lamotrigine
can cause SLE
HIPP, hydralazine, INH, procainamide, phenytoin
Rx w photosensitivity rxn
SAT
sulfonamides, amiodarone, tetracyclines
aplastic anemia
chloramphenicol, benzene, NSAIDs
alkalinize urine helps clr of what rx
weak acids, phenobarbital, MTX, ASA, ??TCA (give NaHCO3)
how can incr clr amphetamines
acidify urine by giving NH4Cl
signs of lead poisoning and tx
encephalopathy, abd colic, lead lines (gingivae and long bones xray), PBS=sideroblastic anemia w basophilic stippling.
tx=dimercaprol, EDTA