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43 Cards in this Set
- Front
- Back
Efects of B2 agonists
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Vasodilatator, diminish periferal resistance, broncodilatador, increase release of glucagon, relax uterine smooth muscle
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Thyramine food
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Avocado, Red wine, aged cheese
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Adrenergic agonist refers to Sympathetic or parasympatetic
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Sympathetic
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What is that MonoAminoOxidase metabolizes?
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Dopamine, Serotonine and norepinefrine that is why I shouldn't ingest any Thyramine while taking antidepressants that are IMAO, because I may cause serotonin crisis
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What happens with blood pressure while taking IMAO's?
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May cause Hypertensive crisis, because increases vasopressure effects;if norepinefrine is not metabolized and it's available in blood will cause vasopressure
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Effects of thyramine
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Desplace norepinephrine and increases it in blood so it causes hipertensive crissis because of it vassopressure efects
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Phenylephrine uses
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Nasal decongestant and mild or moderate hypotension, it causes vasoconstriction so it increases blood pressure
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What VC means in Phenergan VC?
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VasoConstrictor. It has a Alpha 1 agonist (periferal arterial vasoconstrictor)
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Uses of Phenergan VC
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Nasal Congestion and acute hypotension
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Are Alpha 1 and 2 opossites?
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Yes, Alpha 1 are vasoconstrictors and Alpha 2 are peripheral arterial vasodilatators
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Special considerations with alpha 2 agonist drugs? (Catapres, clonidine)
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Discontinue slowly, if not will cause hypertense crisis by reflex
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Beta 1 receptors effects
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Taquicardia, increase heart contractions, that is why we use B1 blockers in HTA
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Beta 1 blockers selective drugs
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Ateneolol, metoprolol, esmolol, betaxolol. Remember at high doses they loose their specificity
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If I have a COPD patient with HTA which betablockers should I use?
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B1 selective blockers,(atenolol, esmolol (IV), metoprolol y betaxolol) to avoid B2 blockage that might affect the lungs in a negative way
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Why is dopamine used in Cardiac Shock after MI? (Severe hypotension)
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Because it stimulates B1 receptors causing more complete and forceful miocardial contraction, increasing blood pressure
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Dopamine and Kydneys
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Dopamine increases blood flow to kydneys
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Dobutamine and End stage Heart Failure
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It increases Cardiac outflow
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First cause of right heart failure
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Left heart failure
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Drugs use in CHF
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ACEI and Betablockers eventhought they cause bradycardia, and it is because it reduces norepinephrine and that reduces miocardial stress, that improves morbi-mortality
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Beta 2 receptors effects
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broncodilatator, increase glucagon release, relaxes smooth uterine muscles (use during early prelabor, to stop it), reduces periferal resistance, taquicardia, increases heart rate, arritmia, that is why in HTA we use B2 blockers
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Symptoms of vagal stimulation
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Low blood pressure, low heart rate,
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Acethylcholine effects
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increase salivation, urination and defecation, increase bronchosecreations, MIOSIS cause by RELAXATION of iris muscle and it makes the pupil to look smaller.
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Why is Ipatropium effective in COPD and not in Asthma?
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Because ipatropium is a anticholinergic that diminish bronquial secretion (antagonist effect of acethylcholine)
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Effects of Cocaine in the eye
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Cause MIDRIASIS because is an simpathetic stimulant and it contracts iris muscles (iris looks bigger)
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Effects of Opioids in the eye
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Cause MIOSIS because is an parasimpathetic stimulant and it relaxes iris muscles (iris looks smaller)
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Bethanechol uses
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Urinary retention, because it stimulates parasypathetic system (is a cholinergic stimulant) and increases the tone in the urinary bladder
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Why is pilocarpine the drug of choice in Glaucoma emergencies?
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Because is a parasympathetic stimulant and cause miosis increasing outflow of aqueous humor, reducing intraocular pressure. Hte drug of choice in regular glaucoma are Betablockers.
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Relationship between acetylcholine and parkinson and Myastenia gravis
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Parkinson is an excessive muscle movement excesive acetylcholine, Myastenia gravis no muscular movement defficit od acetylcholine, that is why treatments are Anticholinergics for Parkinson and Cholinergic for Myastenia gravis
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Ipatropium Contraindication
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Allergies to peanuts and Soy
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Carbonic anhidrase Inhibitor diuretics MOA
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Inhibit the reabsortion of HCO3 in the proximal tubule
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Carbonic anhydrase inhibitors Drugs (diuretics)
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Acetazolamide (DiamoX) Dorzolamide (trusopt) Brinzolamide (Azopt)
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Loop diuretics MOA
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Inhibit sodium reabsortion in th proximal portion of the ascending loop of Henle. THEY ARE THE MOST POTENT DIURETICS
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Loop diuretics drugs
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Bumetanide (Bumex) Ethacrynic acid (edecrin), Furosemide(Lasix) Torsemide (Demadex)
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Thiazides Diuretics MOA
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Inhibit sodium reabsortion at the distal portion of the ascending loop
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Thiazides Diuretics Drugs
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HCTZ (Hydrodiuryl), Chlortalidone (Hygriton), Indapamide (Lozol) Metolazone(Zaroxolyn)
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Potassium-Sparing diuretics Drugs
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Amiloride (Midamor), Triamterene (Dyrenium), Spironolactone (Aldactone)
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Drugs that decrease folic acid
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Colchicine, Phenytoin and sulfalazine
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When to administer Folic acid in patient taking drugs that may cause its deficiency
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Inmediately when the risk start, because you have to avoid potential CNS effects cause by this deficiency
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Drugs that block absortion of folic acid
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Methotrexate and trimetoprim
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Which conditions reduce Folic acid?
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Alcoholism and pregnancy
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Megaloblastic anemia Cause
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Folic acid deficiency
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Iron administration and secondary effects
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In empty stomach, cause dark stools and constipation
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Vit B12 defficience
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CNS effects, sore tongue, weekness
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