C2 Autonomic Pharmacology

Front 1

drug used to treat anaphylactic shock

Back 1

epinephrine

(adrenergic agonist)
promotes sympathetic response

Front 2

metroprolol is used to treat what condition?

Back 2

HTN

b1-adrenergic antagnoist
(blocks sympathetic action)

Front 3

most pre-ganglionic autonomic fibers are

what type of fibers?
what do they release?

Back 3

CHOLINERGIC

Acetylcholine

Front 4

Most post-ganglionic SYMPATHETIC FIBERS are

what type of fibers?
what do they release?

Back 4

NORADRENERGIC FIBERS
release NE

(some sympathetic post-ganglionic fibers release dopamine)

Front 5

Somatic motor fibers are

what type of fibers?
what do they release?
where do they terminate?

Back 5

CHOLINERGIC

release ACh
terminate on skeletal muscle

Front 6

what NTs are released by the adrenal medulla?

what type of nerve fiber is the adrenal medulla similar to?

Back 6

MIX of NE and EPI

similar to postganglionic sympathetic fibers

Front 7

all postganglionic cholinergic fibers respond to ACh via what type of receptor?

Back 7

NICOTINIC

Front 8

resting state, most dually innervated organs are controlled by which branch of the ANS?

Back 8

PANS

(i.e. AT REST, drugs that inhibit PANS have dramatic effect, whereas drugs that inhibit SANS do not)

Front 9

autonomic drug used for treatment of ALZHEIMER's DISEASE

Back 9

Cholinesterase inhibitors
e.g. donepezil

Front 10

Horner's syndrome

Back 10

block in sympathetic nervous system on one side of the face:
pupillary constriction
ptosis
anhydrosis

Front 11

autonomic drug useful in treating septic shock

Back 11

Norepinephrine

adrenergic agonist, useful for predominant effect on alpha-1 ARs

Front 12

autonomic drug useful in treating benign prostatic hypertrophy

Back 12

a-adrenergic ANTAGONIST

DOXAZOSIN

effective in reducing frequency and severity of symptoms by its ability to RELAX SM

Front 13

what two adrenergic receptor signalling pathways have virtually opposite effects?

Back 13

Beta-AR and Alpha2-AR

beta-AR pathway --> + Adenylate Cyclase (increasing cAMP)

Alpha 2AR pathway --> - Adenylate cylcase (decreasing cAMP production)

Front 14

albuterol

Back 14

beta2 adrenergic agonist

useful for the treatment of asthma

Front 15

autonomic drug useful for the treatment of angina

Back 15

metroprolol (also useful for HTN)

b1-adrenergic ANTAGONIST

Front 16

a1-AR pathway causes constriction/contraction of what tissues?

Back 16

blood vessels
bronchi

GI sphincter
uterus
sphincter
seminal tract
iris (radial)

Front 17

what adrenergic receptor bathway causes the relaxation of GI smooth muscle?

Back 17

alpha-2-AR
beta-1-AR

Front 18

what is the tissue action of the beta1-AR?

Back 18

relaxation of GI smooth muscle

Front 19

what dilates by stimulation of the beta2-adrenergic receptors?

Back 19

blood vessels
bronchi

Front 20

what are the tissue effects of beta2-AR signalling?

Back 20

dilation (blood vesels and bronchi)

RELAXATION of:
GI sphincter
uterus
detrussor
seminal tract
ciliary muscle

Front 21

what adrenergic receptor pathway has the most cardiovascular impact?

Back 21

beta-1-AR

increase HR
increase force
increase AV node firing
conduction velocity

Front 22

Which adrenergic receptor pathways effect the liver?

how?

Back 22

a1-AR: gylcogenolysis and K+ release

b2-AR: gylcogenolysis

Front 23

Which adrenergic receptor pathways effect fat?

Back 23

b1-AR: lipolysis

Front 24

Which adrenergic receptor pathways effect the salivary gland?

Back 24

a1-AR: K+ release
b1-AR: amylase release

Front 25

Which adrenergic receptor pathways effect platelets?

Back 25

a2-AR: aggregation

Front 26

Which adrenergic receptor pathways effect mast cells?

Back 26

b2-AR: inhibit histamine release

Front 27

autonomic drug used for the treatment of Heart failure

Back 27

DOPAMINE

b1-adrenergic and dopamine receptor agonist

sympathomimetic promotes vasodilation and SM relaxation

Front 28

D1 and D5 receptors
-found where?
-activate what?

Back 28

post-synaptic receptors distributed in BRAIN and RENAL VASCULATURE

activate AC --> + cAMP

Front 29

D2 receptors
-found where?
-activate what?

Back 29

post-synaptic receptors located in brain and SM

act through Gi proteins to inhibit AC

presynaptic receptors are found on nerve terminals and increase K+ conductance

Front 30

D3 receptors
-found where?
-axn?

Back 30

postsynaptic receptors located primarily in brain

inhibit Adenylyl cyclase

Front 31

D4 receptors
-found where?
-axn?

Back 31

postsynaptic receptors located in brain and CVS

inhibit adenylyl cyclase

Front 32

sympathetic axn on eye happens via which receptors?

Back 32

alpha 1 = contraction of radial muscle (mydriasis)

beta 2 = relaxation of ciliary muscle (far vision)

Front 33

sympathetic axn on heart happens via which receptors?

Back 33

predominantly beta-1=
increased HR via SV node
increased contraction/conduction velocity at atria
increased conduction velocity at AV node, increased contractility and vonduction velocity at ventricles

Front 34

sympathetic axn on lung happens via which receptors?

Back 34

beta2 receptors in bronchial muscle signal relaxation

beta2 receptors in bronchial gland cause sl inhibition

Front 35

major sympathetic action on arteries and veins occurs via which receptors?

Back 35

alpha1 and alpha 2 = CONSTRICTION
beta2 = dilation

Front 36

in stomach and intesting which receptor(s) signal sympathetic action?

Back 36

ALPHA 1
decreases SM tone
causes contraction of sphincters
inhibits secretion

alpha 2 and beta 1 and 2 also decrease motility and tone

Front 37

receptor that signals sympathetic relaxation of the gallbladder

Back 37

beta2

Front 38

anisocoria caused by nebulizer

Back 38

parasympathetic blocker being used to treat asthma got into eye

causing increased sympathetic action on eye (pupil fixed and dilated)