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38 Cards in this Set

  • Front
  • Back
drug used to treat anaphylactic shock

(adrenergic agonist)
promotes sympathetic response
metroprolol is used to treat what condition?

b1-adrenergic antagnoist
(blocks sympathetic action)
most pre-ganglionic autonomic fibers are

what type of fibers?
what do they release?

Most post-ganglionic SYMPATHETIC FIBERS are

what type of fibers?
what do they release?
release NE

(some sympathetic post-ganglionic fibers release dopamine)
Somatic motor fibers are

what type of fibers?
what do they release?
where do they terminate?

release ACh
terminate on skeletal muscle
what NTs are released by the adrenal medulla?

what type of nerve fiber is the adrenal medulla similar to?
MIX of NE and EPI

similar to postganglionic sympathetic fibers
all postganglionic cholinergic fibers respond to ACh via what type of receptor?
resting state, most dually innervated organs are controlled by which branch of the ANS?

(i.e. AT REST, drugs that inhibit PANS have dramatic effect, whereas drugs that inhibit SANS do not)
autonomic drug used for treatment of ALZHEIMER's DISEASE
Cholinesterase inhibitors
e.g. donepezil
Horner's syndrome
block in sympathetic nervous system on one side of the face:
pupillary constriction
autonomic drug useful in treating septic shock

adrenergic agonist, useful for predominant effect on alpha-1 ARs
autonomic drug useful in treating benign prostatic hypertrophy
a-adrenergic ANTAGONIST


effective in reducing frequency and severity of symptoms by its ability to RELAX SM
what two adrenergic receptor signalling pathways have virtually opposite effects?
Beta-AR and Alpha2-AR

beta-AR pathway --> + Adenylate Cyclase (increasing cAMP)

Alpha 2AR pathway --> - Adenylate cylcase (decreasing cAMP production)
beta2 adrenergic agonist

useful for the treatment of asthma
autonomic drug useful for the treatment of angina
metroprolol (also useful for HTN)

b1-adrenergic ANTAGONIST
a1-AR pathway causes constriction/contraction of what tissues?
blood vessels

GI sphincter
seminal tract
iris (radial)
what adrenergic receptor bathway causes the relaxation of GI smooth muscle?
what is the tissue action of the beta1-AR?
relaxation of GI smooth muscle
what dilates by stimulation of the beta2-adrenergic receptors?
blood vessels
what are the tissue effects of beta2-AR signalling?
dilation (blood vesels and bronchi)

GI sphincter
seminal tract
ciliary muscle
what adrenergic receptor pathway has the most cardiovascular impact?

increase HR
increase force
increase AV node firing
conduction velocity
Which adrenergic receptor pathways effect the liver?

a1-AR: gylcogenolysis and K+ release

b2-AR: gylcogenolysis
Which adrenergic receptor pathways effect fat?
b1-AR: lipolysis
Which adrenergic receptor pathways effect the salivary gland?
a1-AR: K+ release
b1-AR: amylase release
Which adrenergic receptor pathways effect platelets?
a2-AR: aggregation
Which adrenergic receptor pathways effect mast cells?
b2-AR: inhibit histamine release
autonomic drug used for the treatment of Heart failure

b1-adrenergic and dopamine receptor agonist

sympathomimetic promotes vasodilation and SM relaxation
D1 and D5 receptors
-found where?
-activate what?
post-synaptic receptors distributed in BRAIN and RENAL VASCULATURE

activate AC --> + cAMP
D2 receptors
-found where?
-activate what?
post-synaptic receptors located in brain and SM

act through Gi proteins to inhibit AC

presynaptic receptors are found on nerve terminals and increase K+ conductance
D3 receptors
-found where?
postsynaptic receptors located primarily in brain

inhibit Adenylyl cyclase
D4 receptors
-found where?
postsynaptic receptors located in brain and CVS

inhibit adenylyl cyclase
sympathetic axn on eye happens via which receptors?
alpha 1 = contraction of radial muscle (mydriasis)

beta 2 = relaxation of ciliary muscle (far vision)
sympathetic axn on heart happens via which receptors?
predominantly beta-1=
increased HR via SV node
increased contraction/conduction velocity at atria
increased conduction velocity at AV node, increased contractility and vonduction velocity at ventricles
sympathetic axn on lung happens via which receptors?
beta2 receptors in bronchial muscle signal relaxation

beta2 receptors in bronchial gland cause sl inhibition
major sympathetic action on arteries and veins occurs via which receptors?
alpha1 and alpha 2 = CONSTRICTION
beta2 = dilation
in stomach and intesting which receptor(s) signal sympathetic action?
decreases SM tone
causes contraction of sphincters
inhibits secretion

alpha 2 and beta 1 and 2 also decrease motility and tone
receptor that signals sympathetic relaxation of the gallbladder
anisocoria caused by nebulizer
parasympathetic blocker being used to treat asthma got into eye

causing increased sympathetic action on eye (pupil fixed and dilated)