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15 Cards in this Set

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  • Back
1. Name the three Components of Innate Immunity
1. Physical barriers
Skin
Mucous membranes and epithelium
2. Biochemical barriers
Antimicrobial substances
Complement
Defensins, lysozyme, others
3. Cells
Phagocytes
Natural killer cells
Mast cells
2. Where are the mast cells most abundant?

CC chemokines attract what?
CXC ?
The skin, mucus membrances, and blood capillary

mononuclear and eosiniphils
neutrophils
3. Three ways the Mucus membrance acts as a defense
1. Physical barrier with mucus and cilia
2. Kill microbes with local ABx
3. Kill microes with local intraepithelial lymphocytes.
4. Main role of complement?

Three sequential processes
induce acute inflammation

Formation of opsonins - CB3 + IGG
Inflammation
Cell lysis
5. Two types of phagocytes

this lymphocytes has granulated cytoplasm, and makes up 10% of lymphocytes
Neutrophils (most numerous)
Macrophages (other fctns also)

Natural Killer Cell
6. When you have a microbe in the tissue, more important than complement activation, this cell needs to recognize the microbe
tissue dendritic cell (both will lead to release on inflammatory mediators
7.Once you get release of inflamm med. 3 things can happen
Inflamm
Fever (IL-1)
Acute Phase Responce (Liver) IL-6
8. How does the innate immune system differ in recognition of microbes that the addaptive system?
Innate is more nonspecific. (# diff microbes bind to same Mannose receptor).

Addaptive is more specific. (T cell Receptors encoded by genes)
9. three examples of innate receptors and their different functional outcomes
Mannose - kill the microbe
toll like recep - same
n-formylmethionyl - chemotaxic for neut, leads to migration into tissues
10. Inflammation leads to infiltration of phagocytic neutrophils in what time period?
and time for macrophages?
first 12-24 hours (cxc)

after 48 hours if needed (cc)
11. 4 activators of macrophages

What is the name of the enzyme that makes RNO from membrane of phagolysosome?
TNF, IL-12, Gamma interferon, LPS

Inducible NO synthase
12. NK Cells and CD4 secrete this cytokine that activates macrophages

How does NK Cell RECOGNIZE cells that need to die?
Gamma IFN

Recognize the Absence of MHC-1 (inhibitory receptor not engaged) Virus will do this, and that is how NK cells target them
13. What is the most important cytokine that stims the liver to release acute phase proteins? Source?
IL-6 from the macrophages, Endothelial, and T cells

Measure E- Sed rate
Cytokine Source Role
TNF

IL-1

Chemokines

IL-12
Source Role
Macro, Tcell Break down muscle, fat, fever, cause apoptosis

macro, endoth Fever

same and T lymth in leuko - chemotaxiz and activation

macro, dendridic, Differential TH1
Cytokine Source Role
Type 1 interferon

IL-10

IL-6
Source Role
macro, fibro impt antiviral role (-rep)

macro TH2 anti inflamm

macro, endo, T cell Liver (see 13) and Proliferation of B cells