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15 Cards in this Set
- Front
- Back
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1. Name the three Components of Innate Immunity
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1. Physical barriers
Skin Mucous membranes and epithelium 2. Biochemical barriers Antimicrobial substances Complement Defensins, lysozyme, others 3. Cells Phagocytes Natural killer cells Mast cells |
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2. Where are the mast cells most abundant?
CC chemokines attract what? CXC ? |
The skin, mucus membrances, and blood capillary
mononuclear and eosiniphils neutrophils |
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3. Three ways the Mucus membrance acts as a defense
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1. Physical barrier with mucus and cilia
2. Kill microbes with local ABx 3. Kill microes with local intraepithelial lymphocytes. |
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4. Main role of complement?
Three sequential processes |
induce acute inflammation
Formation of opsonins - CB3 + IGG Inflammation Cell lysis |
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5. Two types of phagocytes
this lymphocytes has granulated cytoplasm, and makes up 10% of lymphocytes |
Neutrophils (most numerous)
Macrophages (other fctns also) Natural Killer Cell |
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6. When you have a microbe in the tissue, more important than complement activation, this cell needs to recognize the microbe
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tissue dendritic cell (both will lead to release on inflammatory mediators
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7.Once you get release of inflamm med. 3 things can happen
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Inflamm
Fever (IL-1) Acute Phase Responce (Liver) IL-6 |
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8. How does the innate immune system differ in recognition of microbes that the addaptive system?
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Innate is more nonspecific. (# diff microbes bind to same Mannose receptor).
Addaptive is more specific. (T cell Receptors encoded by genes) |
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9. three examples of innate receptors and their different functional outcomes
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Mannose - kill the microbe
toll like recep - same n-formylmethionyl - chemotaxic for neut, leads to migration into tissues |
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10. Inflammation leads to infiltration of phagocytic neutrophils in what time period?
and time for macrophages? |
first 12-24 hours (cxc)
after 48 hours if needed (cc) |
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11. 4 activators of macrophages
What is the name of the enzyme that makes RNO from membrane of phagolysosome? |
TNF, IL-12, Gamma interferon, LPS
Inducible NO synthase |
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12. NK Cells and CD4 secrete this cytokine that activates macrophages
How does NK Cell RECOGNIZE cells that need to die? |
Gamma IFN
Recognize the Absence of MHC-1 (inhibitory receptor not engaged) Virus will do this, and that is how NK cells target them |
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13. What is the most important cytokine that stims the liver to release acute phase proteins? Source?
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IL-6 from the macrophages, Endothelial, and T cells
Measure E- Sed rate |
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Cytokine Source Role
TNF IL-1 Chemokines IL-12 |
Source Role
Macro, Tcell Break down muscle, fat, fever, cause apoptosis macro, endoth Fever same and T lymth in leuko - chemotaxiz and activation macro, dendridic, Differential TH1 |
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Cytokine Source Role
Type 1 interferon IL-10 IL-6 |
Source Role
macro, fibro impt antiviral role (-rep) macro TH2 anti inflamm macro, endo, T cell Liver (see 13) and Proliferation of B cells |
