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20 Cards in this Set

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Corynebacterium Diphtheriae's Toxin?
Diphtheria Toxin
Diphtheria Toxin's MOA?
Inactivates elongation factor EF2
Inactivation of EF2 in C.Diptheria causes what?
pharyngitis and pseudomembrane in throat
Psuedomonas aeruginosa toxin?
Exotoxin A
Exotoxin A MOA?
Inactivate EF2 (same as diphtheria toxin)
Inactivation of EF2 in Psuedomonas causes what?
Host cell death
Shigella; what is the toxin? What is this toxin's MOA? What does this manifest as?
Shiga Toxin (ST)
Inactivates 60S ribosome by cleaving rRNA
GI mucosa damaged --> dysentery; ST also enhances cytokine release causing HUS
EHEC's toxin? That toxin's MOA? Manifestation?
Shiga like toxin (SLT)
Inactivates 60S ribosome by cleaving rRNA
SLT enhances cytokine release causing HUS, does not invade host cell like shigella
ETEC toxin? MOA? Manifestation?
Heat Labile Toxin (LT)
Overactivates cAMP --> increased chloride secretion in gut and water efflux
Watery diarrhea
Another ETEC toxin? MOA? Manifestation?
Heat stable toxin (ST)
overactivates cGMP --> decreased reabsorption of NaCl and H2O in gut
watery diarrhea

Think "Labile in the Air, Stable on the Ground"
Labile --> A (cAMP)
Stable --> G (cGMP)
Yersinia enterocolitica toxin? MOA? Manifestation?
Heat stable toxin
Overactivates cGMP --> decreased reabsorption of NaCl and H2O in gut
bloody diarrhea (y. enterocolitica invades and destroys cells --> dysentary)
Bacillus Anthracus toxin/moa/manifestation?
edema factor
mimics cAMP
edematous borders of black eschar in cutaneous anthrax
vibrio cholera toxin/moa/manifestation?
cholera toxin
overactivates cAMP by permanently activating Gs --> increased chloride secretion in gut and H2O efflux
voluminous rice water stool
Bordatella pertussis toxin/moa/manifestation?
pertussis toxin
overactivates cAMP by disabling Gi, impairing phagocytosis to permit survival of microbe
whooping cough: child coughs on expiration and whoops on inspirations. (toxin may not actually be a cause of cough)
C.Tetani toxin/moa/manifestation?
Tetanospasmin
cleaves SNARE protein required for NT release
muscle rigidity, lock jaw. Toxin prevents release of inhibitory (GABA and glycine) NTs in SC
C.Botulinum toxin/moa/manifestation?
Botulinum toxin
Cleave SNARE protein required for NT release
Flaccid paralysis, floppy baby; toxin prevents release of STIMULATORY (ACh) signals at NMJ --> flaccid paralysis
C. Perfringens toxin/moa/manifestation?
alpha toxin
phospholipase that degrades tissue, cell membranes
Degradation of phospholipids -->myonecrosis (gas gangrene) and hemolysis (double zone of hemolysis on blood agar)
Streptococcus toxin/moa/manifestation?
stretolysin O
protein that degrades cell membrane
Lyses RBC; contributes to Beta hemolysis; host Abs against toxin (ASO) used to dx rheumatic fever
Stretp Pyogenes toxin/moa/manifestation?
Exotoxin A
Bring MHC II and TCR in proximity to cause overwhelming release of IFNy and IL-2 --> shock
toxic shock syndrome: fever/rash/shock
Staph Aureus toxin/moa/manifestation?
TSST-1
Brings MHC II and TCR in proximity to cause overwhelming release of IFNy and IL2 --> shock
Toxic shock syndrome : fever/rash/shock; other toxins cause scalded skin syndrome (exfoliative toxin) and food poisoning (enterotoxin)