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20 Cards in this Set
- Front
- Back
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Corynebacterium Diphtheriae's Toxin?
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Diphtheria Toxin
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Diphtheria Toxin's MOA?
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Inactivates elongation factor EF2
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Inactivation of EF2 in C.Diptheria causes what?
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pharyngitis and pseudomembrane in throat
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Psuedomonas aeruginosa toxin?
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Exotoxin A
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Exotoxin A MOA?
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Inactivate EF2 (same as diphtheria toxin)
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Inactivation of EF2 in Psuedomonas causes what?
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Host cell death
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Shigella; what is the toxin? What is this toxin's MOA? What does this manifest as?
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Shiga Toxin (ST)
Inactivates 60S ribosome by cleaving rRNA GI mucosa damaged --> dysentery; ST also enhances cytokine release causing HUS |
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EHEC's toxin? That toxin's MOA? Manifestation?
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Shiga like toxin (SLT)
Inactivates 60S ribosome by cleaving rRNA SLT enhances cytokine release causing HUS, does not invade host cell like shigella |
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ETEC toxin? MOA? Manifestation?
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Heat Labile Toxin (LT)
Overactivates cAMP --> increased chloride secretion in gut and water efflux Watery diarrhea |
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Another ETEC toxin? MOA? Manifestation?
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Heat stable toxin (ST)
overactivates cGMP --> decreased reabsorption of NaCl and H2O in gut watery diarrhea Think "Labile in the Air, Stable on the Ground" Labile --> A (cAMP) Stable --> G (cGMP) |
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Yersinia enterocolitica toxin? MOA? Manifestation?
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Heat stable toxin
Overactivates cGMP --> decreased reabsorption of NaCl and H2O in gut bloody diarrhea (y. enterocolitica invades and destroys cells --> dysentary) |
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Bacillus Anthracus toxin/moa/manifestation?
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edema factor
mimics cAMP edematous borders of black eschar in cutaneous anthrax |
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vibrio cholera toxin/moa/manifestation?
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cholera toxin
overactivates cAMP by permanently activating Gs --> increased chloride secretion in gut and H2O efflux voluminous rice water stool |
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Bordatella pertussis toxin/moa/manifestation?
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pertussis toxin
overactivates cAMP by disabling Gi, impairing phagocytosis to permit survival of microbe whooping cough: child coughs on expiration and whoops on inspirations. (toxin may not actually be a cause of cough) |
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C.Tetani toxin/moa/manifestation?
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Tetanospasmin
cleaves SNARE protein required for NT release muscle rigidity, lock jaw. Toxin prevents release of inhibitory (GABA and glycine) NTs in SC |
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C.Botulinum toxin/moa/manifestation?
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Botulinum toxin
Cleave SNARE protein required for NT release Flaccid paralysis, floppy baby; toxin prevents release of STIMULATORY (ACh) signals at NMJ --> flaccid paralysis |
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C. Perfringens toxin/moa/manifestation?
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alpha toxin
phospholipase that degrades tissue, cell membranes Degradation of phospholipids -->myonecrosis (gas gangrene) and hemolysis (double zone of hemolysis on blood agar) |
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Streptococcus toxin/moa/manifestation?
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stretolysin O
protein that degrades cell membrane Lyses RBC; contributes to Beta hemolysis; host Abs against toxin (ASO) used to dx rheumatic fever |
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Stretp Pyogenes toxin/moa/manifestation?
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Exotoxin A
Bring MHC II and TCR in proximity to cause overwhelming release of IFNy and IL-2 --> shock toxic shock syndrome: fever/rash/shock |
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Staph Aureus toxin/moa/manifestation?
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TSST-1
Brings MHC II and TCR in proximity to cause overwhelming release of IFNy and IL2 --> shock Toxic shock syndrome : fever/rash/shock; other toxins cause scalded skin syndrome (exfoliative toxin) and food poisoning (enterotoxin) |
