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8 Cards in this Set
- Front
- Back
equilibrium potential
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the diffusion potential that exactly balances the tendency for diffusion created by a concentration difference
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tetrodotoxin, Lidocaine
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block voltage sensitive Na+ channels --> block action potentials in the nerve
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hyperkalemia
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an example of ACCOMODATION: maintaing the cell membrane at at a depolarized level --> the Na+ channels cannot 'reset'. These Na+ channels close their inactivation gates during an AP and only reopen them in a hyperpolarized/resting state. Therefore APs cannot occur, and profound muscle weakness occurs.
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choline acetyltransferase
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catalyzes (Ach) formation of Acetylcholine from Acetyl CoA + Choline. Occurs in presynaptic nerve terminal. Ach is then stored in synaptic vesicles with ATP + proteoglycan)
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nicotinic Ach receptor - what type of receptor is it?
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ligand gated ion channel permeable to Na+/K+
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End Plate potential
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A depolarization of the specialized muscle endplate. The summation of several minature end plate potentials created by the opening of the Na+/K+ ligand gated Ach channels on the post-synaptic membrane. DOES NOT generate an action potential
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Myasthenia Gravis
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Skeletal muscle weakness/fatiguability. Reduced # Ach receptors on the muscle end plate --> decreased EPP --> less able to spread the depolarization and allow the muscle to generate APs. Tx = neostigmine
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ionotropic receptor
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ligand gated ion channel eg. NMDA receptor for glutamate.
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